Drug General Information (ID: DDIT4KM1ZS)
Drug Name			Norepinephrine		Drug Info		Cocaine (nasal)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Anesthetics
Structure

Mechanism of Norepinephrine-Cocaine (nasal) Interaction (Severity Level: Major)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Norepinephrine				Cocaine (nasal)
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Norepinephrine and Cocaine (nasal)

Recommended Action
Management		Concomitant use of cocaine with sympathomimetic agents should be avoided. If coadministration is required, prolonged vital sign and ECG monitoring may be necessary.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Thevasagyam M, Jindal M, Allsop P, Oates J "Does epinephrine infiltration in septoplasty make any difference?" Eur Arch Otorhinolaryngol 264 (2007): 1175-8.[PMID: 17530270]
3	Product Information. Cocaine Hydrochloride (cocaine topical). Mallinckrodt Medical Inc, St. Louis, MO.