Details of Drug

Drug General Information (ID: D0377)
Drug Name	Cocaine (nasal)
Drug Type	Small molecule
Drug Synonymous	Allococaine; Allopseudococaine; Badrock; Bazooka; Benzoylethylecgonine; Benzoylmethylecgonine; Bernice; Bernies; Blast; Blizzard; Blow; Burese; COC; Cabello; Candy; Carrie; Caviar; Cecil; Charlie; Cholly; Coca; Cocain; Cocaina; Cocainum; Cocktail; Coke; Cola; Corine; Crack; Eritroxilina; Erytroxylin; Flake; Flex; Freeze; Girl; Goofball; Heaven; Hell; Jam; Kokain; Kokan; Kokayeen; Lady; Leaf; Moonrocks; Neurocaine; Pseudoallococaine; Rock; Sleighride; Snort; Snow; Toke; Toot; Trails; Yeyo; Bernice [Street Name]; Blow [Street Name]; Bouncing Powder; Cecil [Street Name]; Chicken Scratch; Cocaine [BAN]; Cocaine free base; Cocaine solution; Crack cocaine; Dama blanca; Ecgonine methyl ester benzoate; Ecgonine methyl ester benzoate solution; Flake [Street Name]; Florida Snow; Foo Foo; Girl [Street Name]; Gold dust; Gold dust [Street Name]; Green gold; Happy dust; Happy dust [Street Name]; Happy powder; Happy trails; Lady [Street Name]; Methyl Benzoylecgonine; Nose candy; Prime Time; Rock [Street Name]; Sweet Stuff; Toot [Street Name]; White girl or lady; Beta-Cocain; C" Carrie; Cocaine (TN); Cocaine (USP); Cocaine-M; G-Rock; Kibbles n' Bits; L-Cocain; L-Cocaine; Pimp's drug; Snow (birds); Star-spangled powder; Ecgonine, methyl ester, benzoate (ester); Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester); Methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate; Methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; Methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; (-)-Cocaine; (-)-Cocaine base; (1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate; (1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate; (R)-Cocaine; 1-Cocaine; 2-beta-Carbomethoxy-3-beta-benzoxytropane; 2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester); 2beta-Carbomethoxy-3beta-benzoxytropane; 3-Tropanylbenzoate-2-carboxylic acid methyl ester; 3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester) Click to Show/Hide
Disease Class	9A76-9A78: Corneal disease
Therapeutic Class	Anesthetics
Structure
Structure	3D Structure		2D Structure
Formula	C17H21NO4
InChI	1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1
InChIKey	ZPUCINDJVBIVPJ-LJISPDSOSA-N
Canonical SMILES	CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC
External Link
	Pubchem ID	446220
	CAS Number	50-36-2
	CHEBI ID	27958
	TTD ID	D04XPW
	INTEDE ID	DR0365
	VARIDT ID	DR00530

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM041 Additive hypertensive effects BM061 Increased risk of hyperpyrexia BM069 Increased risk of lowers seizure threshold BM071 Increased risk of methemoglobinemia BM078 Increased risk of rapid heart rate
Relation Graph

Full list of drugs interacting with Cocaine (nasal)
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[18], [19]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[20], [21]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[27]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[18], [19]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[20], [21]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[28], [29], [30]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[23], [32], [33]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1], [36], [37]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[29], [38], [39]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[42], [43], [44]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[45], [46], [47]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[48], [49], [33]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[29], [1], [50]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[54]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[58], [59], [41]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[29], [1], [60]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[22], [23], [24]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[55], [56], [57]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[40], [41], [33]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[40], [41], [33]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[40], [41], [33]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 57
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3]
D0074		Amphetamine	C9H13N	3007	Major		Inter Info	[1], [2], [3]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3]
D0165		Benzphetamine	C17H21N	5311017	Major		Inter Info	[1], [2], [3]
D0231		Caffeine	C8H10N4O2	2519	Major		Inter Info	[1], [2], [3]
D0103		Arformoterol	C19H24N2O4	3083544	Major		Inter Info	[1], [2], [3]
D0106		Armodafinil	C15H15NO2S	9690109	Major		Inter Info	[1], [2], [3]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3]
D0460		Dexmethylphenidate	C14H19NO2	154101	Major		Inter Info	[1], [2], [3]
D0465		Dextroamphetamine	C9H13N	5826	Major		Inter Info	[1], [2], [3]
D0486		Diethylpropion	C13H19NO	7029	Major		Inter Info	[1], [2], [3]
D0517		Dopamine	C8H11NO2	681	Major		Inter Info	[1], [2], [3]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3]
D0538		Droxidopa	C9H11NO5	92974	Major		Inter Info	[1], [2], [3]
D0579		Ephedrine	C10H15NO	9294	Major		Inter Info	[1], [2], [3]
D0691		Formoterol	C19H24N2O4	3410	Major		Inter Info	[1], [2], [3]
D0744		Guanethidine	C10H22N4	3518	Major		Inter Info	[1], [2], [3]
D0797		Indacaterol	C24H28N2O3	6918554	Major		Inter Info	[1], [2], [3]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[1], [2], [3]
D0921		Levonordefrin	C9H13NO3	164739	Major		Inter Info	[1], [2], [3]
D0924		Levosalbutamol	C13H21NO3	123600	Major		Inter Info	[1], [2], [3]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2], [3]
D1002		Mephentermine	C11H17N	3677	Major		Inter Info	[1], [2], [3]
D1012		Metamfetamine	C10H15N	10836	Major		Inter Info	[1], [2], [3]
D1171		Olodaterol	C21H26N2O5	11504295	Major		Inter Info	[1], [2], [3]
D1243		Pemoline	C9H8N2O2	4723	Major		Inter Info	[1], [2], [3]
D1262		Phendimetrazine	C12H17NO	30487	Major		Inter Info	[1], [2], [3]
D1298		Pirbuterol	C12H20N2O3	4845	Major		Inter Info	[1], [2], [3]
D1374		Racepinephrine	C9H13NO3	838	Major		Inter Info	[1], [2], [3]
D1438		Salbutamol	C13H21NO3	2083	Major		Inter Info	[1], [2], [3]
D1440		Salmeterol	C25H37NO4	5152	Major		Inter Info	[1], [2], [3]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Major		Inter Info	[1], [2], [3]
D0510		Dobutamine	C18H23NO3	36811	Major		Inter Info	[1], [2], [3]
D0523		Doxapram	C24H30N2O2	3156	Major		Inter Info	[1], [2], [3]
D0581		Epinephrine	C9H13NO3	5816	Major		Inter Info	[1], [2], [3]
D0583		Epinephrine (topical)	C9H13NO3	5816	Major		Inter Info	[1], [2], [3]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[1], [2], [3]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3]
D0854		Isoetharine	C13H21NO3	3762	Major		Inter Info	[1], [2], [3]
D0981		Mazindol	C16H13ClN2O	4020	Major		Inter Info	[1], [2], [3]
D1013		Metaraminol	C9H13NO2	5906	Major		Inter Info	[1], [2], [3]
D1027		Methoxamine	C11H17NO3	6082	Major		Inter Info	[1], [2], [3]
D1039		Methylphenidate	C14H19NO2	4158	Major		Inter Info	[1], [2], [3]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1], [2], [3]
D1153		Norepinephrine	C8H11NO3	439260	Major		Inter Info	[1], [2], [3]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[1], [2], [3]
D1270		Phentermine	C10H15N	4771	Major		Inter Info	[1], [2], [3]
D1276		Phenylephrine	C9H13NO2	6041	Major		Inter Info	[1], [2], [3]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3]
D1393		Reserpine	C33H40N2O9	5770	Major		Inter Info	[1], [2], [3]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[1], [2], [3]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[1], [2], [3]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[29], [1], [31]
	Increased risk of hyperpyrexia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[10], [11], [12]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[10], [11], [12]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[10], [11], [12]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[10], [11], [12]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[10], [11], [12]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[10], [11], [12]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[10], [11], [12]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[10], [11], [12]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[4], [5], [6]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[7], [8], [9]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[7], [8], [9]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[13], [14], [15]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[25], [26]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[34], [35], [1]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[34], [35], [1]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[34], [35], [1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[29], [1]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[51], [52], [53]
	Increased risk of methemoglobinemia					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[1], [16], [17]
D0065		Aminosalicylic acid	C7H7NO3	4649	Moderate		Inter Info	[1], [16], [17]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[1], [16], [17]
D1752		Bupivacaine (liposome)	C18H28N2O	2474	Moderate		Inter Info	[1], [16], [17]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[1], [16], [17]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[1], [16], [17]
D0319		Chloroprocaine	C13H19ClN2O2	8612	Moderate		Inter Info	[1], [16], [17]
D0622		Etidocaine	C17H28N2O	37497	Moderate		Inter Info	[1], [16], [17]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[1], [16], [17]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[1], [16], [17]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[1], [16], [17]
D1004		Mepivacaine	C15H22N2O	4062	Moderate		Inter Info	[1], [16], [17]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[1], [16], [17]
D1261		Phenazopyridine	C11H11N5	4756	Moderate		Inter Info	[1], [16], [17]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[1], [16], [17]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[1], [16], [17]
D1468		Silver nitrate (ophthalmic)	AgNO3	24470	Moderate		Inter Info	[1], [16], [17]
D1469		Silver nitrate (topical)	AgNO3	24470	Moderate		Inter Info	[1], [16], [17]
D1470		Silver sulfadiazine (topical)	C10H9AgN4O2S	441244	Moderate		Inter Info	[1], [16], [17]
D1530		Tafenoquine	C24H28F3N3O3	115358	Moderate		Inter Info	[1], [16], [17]
D1561		Tetracaine	C15H24N2O2	5411	Moderate		Inter Info	[1], [16], [17]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[1], [16], [17]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Moderate		Inter Info	[1], [16], [17]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[1], [16], [17]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[1], [16], [17]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[1], [16], [17]
D1144		Nitric Oxide	NO	145068	Moderate		Inter Info	[1], [16], [17]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[1], [16], [17]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[1], [16], [17]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[1], [16], [17]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[1], [16], [17]
D1344		Procaine	C13H20N2O2	4914	Moderate		Inter Info	[1], [16], [17]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1], [16], [17]
D1386		Rasburicase	NA	NA	Moderate		Inter Info	[1], [16], [17]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[1], [16], [17]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[1], [16], [17]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[1], [16], [17]

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