Drug General Information (ID: DDIT1QGPNU)
Drug Name			Sucralfate		Drug Info		Prochlorperazine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Antipsychotic Agents
Structure

Mechanism of Sucralfate-Prochlorperazine Interaction (Severity Level: Minor)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Prochlorperazine
Mechanism		Antacid				Adsorbed by antacids
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Prochlorperazine due to adsorption of Sucralfate

References
1	Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):.
2	Fann WE "Interactions of psychotropic drugs in the elderly." Postgrad Med 53 (1973): 182-6. [PMID: 4144160]
3	Fann WE, Davis JM, Janowsky DS, Sekerke HJ, Schmidt DM "Chlorpromazine: effects of antacids on its gastrointestinal absorption." J Clin Pharmacol 13 (1973): 388-90. [PMID: 4355737]
4	Forrest FM, Forrest IS, Serra MT "Modification of chlorpromazine metabolism by some other drugs frequently administered to psychiatric patients." Biol Psychiatry 2 (1970): 53-8. [PMID: 5414905]
5	Romankiewicz JA "Effects of antacids on gastrointestinal absorption of drugs." Prim Care 3 (1976): 537-50. [PMID: 61596]