Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDISWX1GDZ)
  Drug Name Nitroprusside Drug Info Nitric Oxide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Bronchodilators
  Structure

 Mechanism of Nitroprusside-Nitric Oxide Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nitroprusside Nitric Oxide
      Mechanism 1 Hypotensive effects
Guanylate cyclase  Agonist 		Hypotensive effects
Guanylate cyclase  Agonist
      Key Mechanism Factor 1
Factor Name Guanylate cyclase soluble Structure Sequence
Protein Family Adenylyl cyclase class-4/guanylyl cyclase family
Protein Function
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Nitroprusside and Nitric Oxide 
     Increased risk of methemoglobinemia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nitroprusside Nitric Oxide
      Mechanism 2 Methemoglobinemia Methemoglobinemia
      Key Mechanism Factor 2
Factor Name Methemoglobinemia
Factor Description Methemoglobinemia is a condition in which higher than normal levels of methemoglobin are found in the blood. Methemoglobinemia is a potentially life-threatening condition in which the oxygen-carrying capacity of circulating hemoglobin is reduced due to the conversion of some or all of the four iron species from the reduced ferrous (Fe2+) state to the oxidized iron (Fe3+) state.
      Mechanism Description
  • Increased risk of methemoglobinemia by the combination of Nitroprusside and Nitric Oxide 

Recommended Action
      Management Until more data are available, it may be advisable to monitor methemoglobin levels, especially in patients with respiratory insufficiency, anemia, or cardiovascular disease. Patients should also be monitored for hypotension.

References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".