Details of Drug | MecDDI

Drug General Information (ID: D1144)
Drug Name		Nitric Oxide
Drug Type		Small molecule
Drug Synonymous		Nitric oxide; nitric oxide; nitrogen monoxide; Mononitrogen monoxide; 10102-43-9; nitrogen monooxide; nitrogen protoxide; nitrosyl; Nitrosyl radical; EDRF; CHEBI:16480; endothelium-derived relaxing factor; monoxyde d'azote; oxoazanyl; oxyde azotique; oxido nitrico; Stickstoffmonoxid; Nitric oxide trimer; monoxido de nitrogeno; Stickstoff(II)-oxid; Nitric oxide (JAN); INOmax (TN); oxido de nitrogeno(II); Nitrosoradical; [NO]; oxidonitrogen(); Nitrogen(II) oxide; OHM 11771; AC1L3QHF; Nitric oxide, 985%; DTXSID1020938; CHEMBL1200689; CTK0H7679; ()NO; HNO; INOmax; Nitrosyl; Nitroxyl; Oxoazanyl; Stickmonoxyd; Endogenous Nitrate Vasodilator; Monoxido de nitrogeno; Nitrogen monooxide; Nitrogen monoxide; Nitrosyl hydride; Nitroxide radical; Oxido nitrico; Oxyde azotique; Oxyde nitrique [French]; Stickmonoxyd [German]; Bioxyde d'azote; Bioxyde d'azote [French]; Endothelium-Derived Nitric Oxide; Monoxide, Mononitrogen; Monoxide, Nitrogen; Monoxyde d'azote; NITRIC-OXIDE; NO(); Nitrate Vasodilator, Endogenous; Nitric Oxide, Endothelium Derived; Nitric oxide 10% by volume or more; Nitric oxide, compressed [UN1660] [Poison gas]; Nitrogen oxide (NO); Oxide, Nitric; Oxido de nitrogeno(II); Oxidonitrogen(); Vasodilator, Endogenous Nitrate; Nitric Oxide, Endothelium-Derived; Nitrosyl hydride ((NO)H); Endothelium-derived relaxing factor (EDRF) Click to Show/Hide
Disease Class		CB41: Respiratory failure; 2A00-2F9Z: Solid tumour/cancer; 1F28: Dermatophytosis
Therapeutic Class		Bronchodilators
Structure
Structure		3D Structure				2D Structure
Formula		NO
InChI		1S/NO/c1-2
InChIKey		MWUXSHHQAYIFBG-UHFFFAOYSA-N
Canonical SMILES		[N]=O
External Link
		Pubchem ID		145068
		CAS Number		10102-43-9
		CHEBI ID		16480
		TTD ID		D0A5FM
		VARIDT ID		DR01184

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM042 Additive hypotensive effects BM071 Increased risk of methemoglobinemia
Relation Graph

Full list of drugs interacting with Nitric Oxide
Pharmacodynamic additive effects
					Additive hypotensive effects																																																																Drug Num: 2
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D1146															Nitroglycerin															C3H5N3O9															4510															Moderate															Inter Info													[6]
D1147															Nitroprusside															C5FeN6O															11953891															Moderate															Inter Info													[6]
					Increased risk of methemoglobinemia																																																																Drug Num: 12
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D1148															Nitrous acid															HNO2															24529															Major															Inter Info													[1], [2], [3]
D1337															Prilocaine															C13H20N2O															4906															Major															Inter Info													[4], [5], [6], [7], [8], [9], [10]
D1835															Lidocaine (ophthalmic)															C14H22N2O															3676															Moderate															Inter Info													[6], [7], [11]
D0928															Lidocaine (topical)															C14H22N2O															3676															Moderate															Inter Info													[6], [7], [11]
D0163															Benzocaine (topical)															C9H11NO2															2337															Moderate															Inter Info													[6], [7], [11]
D0339															Cinchocaine (topical)															C20H29N3O2															3025															Moderate															Inter Info													[6], [7], [11]
D0377															Cocaine (nasal)															C17H21NO4															446220															Moderate															Inter Info													[6], [7], [11]
D0378															Cocaine (topical)															C17H21NO4															446220															Moderate															Inter Info													[6], [7], [11]
D1852															Oxybuprocaine (ophthalmic)															C17H28N2O3															4633															Moderate															Inter Info													[6], [7], [11]
D1870															Proparacaine (ophthalmic)															C16H26N2O3															4935															Moderate															Inter Info													[6], [7], [11]
D1904															Tetracaine (ophthalmic)															C15H24N2O2															5411															Moderate															Inter Info													[6], [7], [11]
D1562															Tetracaine (topical)															C15H24N2O2															5411															Moderate															Inter Info													[6], [7], [11]

References
1	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
2	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
3	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
4	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
5	Cerner Multum, Inc. "Australian Product Information.".
6	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
7	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
8	Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
9	Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
10	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
11	Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.