Drug General Information (ID: DDIST1VZDF)
Drug Name			Mycophenolate mofetil		Drug Info		Paromomycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Immunosuppressive Agents				Antibiotics
Structure

Mechanism of Mycophenolate mofetil-Paromomycin Interaction (Severity Level: Moderate)
Altered intestinal flora Click to Show/Hide Mechanism Graph
Drug Name		Mycophenolate mofetil				Paromomycin
Mechanism		Affected by alters GI flora				Alters GI flora
Key Mechanism Factor 1
		Factor Name		Intestinal flora
		Factor Description		The intestinal flora has multiple effects on human health, and altering the intestinal microbiota can affect the absorption of drugs and alter their pharmacological effects.
Mechanism Description		Altered absorption of Mycophenolate mofetil due to GI flora changes caused by Paromomycin

Recommended Action
Management		Close clinical and laboratory monitoring for evidence of diminished immunosuppressive effect of mycophenolic acid is recommended during concomitant therapy with anti-infective agents.

References
1	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
2	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.