Details of Drug

Drug General Information (ID: D1228)
Drug Name	Paromomycin
Drug Type	Small molecule
Drug Synonymous	Aminosidin; Catenulin; Humatin; Hydroxymycin sulfate; Paramomycin Sulfate; Paromomycin I; Paromomycin sulfate Rx346208; Aminosidine, sulfate; HATT & Paromomycin; Humatin (TN); Paromomycin (INN); Paromomycin (TN); Paromomycin (complex); PA1-PA2-PA3-PA4; Human .alpha.-1-antitrypsin & Paromomyin; PAROMOMYCIN I, AMMINOSIDIN, CATENULIN, CRESTOMYCIN, MONOMYCIN A, NEOMYCIN E; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside; (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol; O-2-Amino-2-deoxy-.alpha.-D-glucopyranosyl-(1->4)-O-[O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1->3)-.beta.D-ribofuranosyl(1->5)]-2-deoxy-D-streptamine Click to Show/Hide
Disease Class	1A36: Amoebiasis
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C23H45N5O14
InChI	1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey	UOZODPSAJZTQNH-LSWIJEOBSA-N
Canonical SMILES	C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
External Link
	Pubchem ID	165580
	CAS Number	7542-37-2
	CHEBI ID	7934
	TTD ID	D04NDM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM009 Altered absorption (Unspecific) BM014 Interference of cell/tissue uptake BM045 Additive neuromuscular blocking effects BM066 Increased risk of hypomagnesemia BM072 Increased risk of nephrotoxicity BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Paromomycin
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[30], [31]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[30], [31]
	Altered absorption (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[27], [28], [29]
D0491		Digoxin	C41H64O14	2724385	Minor		Inter Info	[41], [42], [43]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[33]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[34], [35], [36]
Pharmacodynamic additive effects
	Additive neuromuscular blocking effects					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D0522		Doxacurium	C56H78N2O16+2	60169	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1047		Metocurine	C40H48N2O6+2	21233	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1080		Mivacurium	C58H80N2O14+2	5281042	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1219		Pancuronium	C35H60N2O4+2	441289	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D0122		Atracurium	C53H72N2O12+2	47319	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1384		Rapacuronium	C37H61N2O4+	5311399	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1295		Pipecuronium	C35H62N4O4+2	50192	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1420		Rocuronium	C32H53N2O4+	441290	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1510		Succinylcholine	C14H30N2O4+2	5314	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1659		Tubocurarine	C37H41N2O6+	6000	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1684		Vecuronium	C34H57N2O4+	39765	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[1], [32], [18], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[1], [32], [18], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
	Increased risk of hypomagnesemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[23]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[23]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[23]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[23]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[23]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[23]
	Increased risk of nephrotoxicity					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[22]
D1672		Valaciclovir	C13H20N6O4	135398742	Moderate		Inter Info	[18], [40]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[18], [19], [20]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[21]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[24], [25], [26]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[24], [25], [26]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[24], [25], [26]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[37], [38], [39]

References
1	Burkett L, Bikhazi GB, Thomas KC Jr, Rosenthal DA, Wirta MG, Foldes FF "Mutual potentiation of the neuromuscular effects of antibiotics and relaxants." Anesth Analg 58 (1979): 107-15. [PMID: 571233]
2	Chapple DJ, Clark JL, Hughes R "Interaction between atracurium and drugs used in anaesthesia." Br J Anaesth 55 Suppl (1983): s17-22. [PMID: 6688011]
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4	Geha DG, Blitt CD, Moon BJ "Prolonged neuromuscular blockade with pancuronium in the presence of acute renal failure: a case report." Anesth Analg 55 (1976): 343-5. [PMID: 945014]
5	Giala M, Sareyiannis C, Cortsaris N, Paradelis A, Lappas DG "Possible interaction of pancuronium and tubocurarine with oral neomycin." Anaesthesia 37 (1982): 776. [PMID: 7103026]
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13	Product Information. Arikayce (amikacin liposome). Insmed Incorporated, Bridgewater, NJ.
14	Product Information. Humatin (paromomycin). Parke-Davis, Morris Plains, NJ.
15	Regan AG, Perumbetti PP "Pancuronium and gentamicin interaction in patients with renal failure." Anesth Analg 59 (1980): 393. [PMID: 6989291]
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18	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
19	UK government "Typhoid.".
20	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
21	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
22	Motuz DJ, Watson WA, Barlow JC, et al "The increase in urinary alanine aminopeptidase excretion associated with enflurane anesthesia is increased further by aminoglycosides." Anesth Analg 67 (1988): 770-4. [PMID: 2899408]
23	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
24	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
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30	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
31	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
32	Cerner Multum, Inc. "Australian Product Information.".
33	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
34	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
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36	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
37	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
38	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
39	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
40	Product Information. Valtrex (valacyclovir). Glaxo Wellcome, Research Triangle Park, NC.
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43	Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44. [PMID: 3056649]

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