Drug General Information (ID: DDISGC8A5M)
Drug Name			Ponatinib		Drug Info		Magnesium hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Multikinase Inhibitors				Antacids/Laxatives
Structure

Mechanism of Ponatinib-Magnesium hydroxide Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ponatinib				Magnesium hydroxide
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Ponatinib due to altered gastric pH caused by Magnesium hydroxide

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.