Drug General Information (ID: DDISEIZ7CO)
Drug Name			Rituximab		Drug Info		Upadacitinib		Drug Info
Drug Type		Monoclonal antibody				Small molecule
Therapeutic Class		Antineoplastics				Antirheumatics

Mechanism of Rituximab-Upadacitinib Interaction (Severity Level: Major)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Rituximab				Upadacitinib
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Rituximab and Upadacitinib

Recommended Action
Management		Concomitant use of upadacitinib with other JAK inhibitors, biologic disease-modifying antirheumatic drugs (bDMARDs), or potent immunosuppressants (e.g., azathioprine, cyclosporine) is not recommended. Patients receiving upadacitinib should be closely monitored for the development of signs and symptoms of infection during and after treatment, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy. If a serious or opportunistic infection develops, upadacitinib should be interrupted until the infection is controlled.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.