Details of Drug

Drug General Information (ID: D1666)
Drug Name	Upadacitinib
Drug Type	Small molecule
Drug Synonymous	ABT-494 Click to Show/Hide
Disease Class	EA80: Atopic eczema; FA21: Psoriatic arthritis; DD70: Crohn disease; DD71: Ulcerative colitis; FA20: Rheumatoid arthritis
Therapeutic Class	Antirheumatics
Structure
Structure	3D Structure		2D Structure
Formula	C17H19F3N6O
InChI	1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
InChIKey	WYQFJHHDOKWSHR-MNOVXSKESA-N
Canonical SMILES	CCC1CN(CC1C2=CN=C3N2C4=C(NC=C4)N=C3)C(=O)NCC(F)(F)F
External Link
	Pubchem ID	58557659
	CAS Number	1310726-60-3
	TTD ID	D07JAG
	INTEDE ID	DR1660

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Upadacitinib
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[2]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[2]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[2]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[2]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[2]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[2]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[2]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[2]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[2]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[2]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[2]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[2]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[2]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[2]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[2]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[2]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[2]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[2]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[2]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[2]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[2]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[2]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[23]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[2]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[2]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[2]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[2]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[2]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[32], [33]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[2]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[2]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[2]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[2]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[2]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[2]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[36]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[2]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[9], [1], [39]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[40]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[2]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[42]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[9], [1], [43], [44]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[2]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[2]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[2]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[2]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[2]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[2]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[59], [60]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[2]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[2]
	CYP450 enzyme induction					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[2]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[13], [2]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[2]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[2]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[13], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[2]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[9], [35]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[2]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[2]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[2]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[2]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[2]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[2]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[2]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[2]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[2]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[9], [1], [48]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[9], [1], [49], [48]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [51]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[9], [1], [48]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[61], [62], [63], [64], [65]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 219
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0004		Abatacept	NA	NA	Major		Inter Info	[1], [2]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[2]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[2]
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2]
D0027		Aflibercept	NA	NA	Major		Inter Info	[2]
D0030		Aldesleukin	NA	NA	Major		Inter Info	[2]
D0032		Alefacept	NA	NA	Major		Inter Info	[2]
D0033		Alemtuzumab	NA	NA	Major		Inter Info	[2]
D0048		Altretamine	C9H18N6	2123	Major		Inter Info	[2]
D0085		Anakinra	C20H23N5O7S2	146171046	Major		Inter Info	[1], [2]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Major		Inter Info	[2]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Major		Inter Info	[2]
D0114		Asparaginase Escherichia coli	NA	NA	Major		Inter Info	[2]
D0118		Atezolizumab	NA	NA	Major		Inter Info	[2]
D0132		Axicabtagene ciloleucel	NA	NA	Major		Inter Info	[2]
D0134		Azacitidine	C8H12N4O5	9444	Major		Inter Info	[2]
D0136		Azathioprine	C9H7N7O2S	2265	Major		Inter Info	[2]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[2]
D0147		Basiliximab	NA	NA	Major		Inter Info	[2]
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Major		Inter Info	[2]
D0151		Belatacept	NA	NA	Major		Inter Info	[2]
D0152		Belimumab	NA	NA	Major		Inter Info	[2]
D0153		Belinostat	C15H14N2O4S	6918638	Major		Inter Info	[2]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Major		Inter Info	[2]
D0172		Betamethasone	C22H29FO5	9782	Major		Inter Info	[2]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[2]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Major		Inter Info	[2]
D0191		Blinatumomab	NA	NA	Major		Inter Info	[2]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[2]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[2]
D0199		Brentuximab vedotin	NA	NA	Major		Inter Info	[2]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[2]
D0209		Brodalumab	NA	NA	Major		Inter Info	[2]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[2]
D0223		Busulfan	C6H14O6S2	2478	Major		Inter Info	[2]
D0227		Cabazitaxel	C45H57NO14	9854073	Major		Inter Info	[2]
D0246		Canakinumab	NA	NA	Major		Inter Info	[2]
D0249		Capecitabine	C15H22FN3O6	60953	Major		Inter Info	[2]
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[2]
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[2]
D0264		Carmustine	C5H9Cl2N3O2	2578	Major		Inter Info	[2]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [2]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Major		Inter Info	[2]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[2]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [6]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[2]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[2]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[2]
D0392		Corticotropin	C207H308N56O58S	16132265	Major		Inter Info	[2]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Major		Inter Info	[2]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[2]
D0404		Cytarabine	C9H13N3O5	6253	Major		Inter Info	[2]
D0407		Dacarbazine	C6H10N6O	135398738	Major		Inter Info	[2]
D0410		Dactinomycin	C62H86N12O16	457193	Major		Inter Info	[2]
D0422		Daratumumab	NA	NA	Major		Inter Info	[2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[2]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[2]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[2]
D0431		Decitabine	C8H12N4O4	451668	Major		Inter Info	[2]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[2]
D0442		Denileukin diftitox	NA	NA	Major		Inter Info	[2]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[2]
D0499		Dimethyl fumarate	C6H8O4	637568	Major		Inter Info	[2]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[2]
D0507		Diroximel fumarate	C11H13NO6	73330464	Major		Inter Info	[2]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[2]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[2]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[2]
D0540		Dupilumab	NA	NA	Major		Inter Info	[2]
D0541		Durvalumab	NA	NA	Major		Inter Info	[2]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[2]
D0553		Efalizumab	NA	NA	Major		Inter Info	[2]
D0560		Elotuzumab	NA	NA	Major		Inter Info	[2]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[2]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[2]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2]
D0627		Etoposide	C29H32O13	36462	Major		Inter Info	[2]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[2]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[12]
D0666		Floxuridine	C9H11FN2O5	5790	Major		Inter Info	[2]
D0669		Fludarabine	C10H12FN5O4	657237	Major		Inter Info	[2]
D0671		Fludrocortisone	C21H29FO5	31378	Major		Inter Info	[2]
D0675		Fluorouracil	C4H3FN2O2	3385	Major		Inter Info	[2]
D0714		Gemcitabine	C9H11F2N3O4	60750	Major		Inter Info	[2]
D0717		Gemtuzumab ozogamicin	NA	NA	Major		Inter Info	[2]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2]
D0747		Guselkumab	NA	NA	Major		Inter Info	[2]
D0773		Hydrocortisone	C21H30O5	5754	Major		Inter Info	[2]
D0780		Hydroxyurea	CH4N2O2	3657	Major		Inter Info	[2]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[2]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[2]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[2]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Major		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[2]
D0801		Inebilizumab	NA	NA	Major		Inter Info	[2]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[2]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[2]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[2]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[2]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[2]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[2]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[2]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[2]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[2]
D0851		Isatuximab	NA	NA	Major		Inter Info	[2]
D0873		Ixabepilone	C27H42N2O5S	6445540	Major		Inter Info	[2]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[2]
D0875		Ixekizumab	NA	NA	Major		Inter Info	[2]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[2]
D0910		Levamisole	C11H12N2S	26879	Major		Inter Info	[2]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[2]
D0945		Lomustine	C9H16ClN3O2	3950	Major		Inter Info	[2]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[2]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[2]
D0986		Mechlorethamine	C5H11Cl2N	4033	Major		Inter Info	[2]
D0996		Melphalan	C13H18Cl2N2O2	460612	Major		Inter Info	[2]
D1007		Mercaptopurine	C5H4N4S	667490	Major		Inter Info	[2]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[2]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[2]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[2]
D1077		Mitomycin	C15H18N4O5	5746	Major		Inter Info	[2]
D1079		Mitoxantrone	C22H28N4O6	4212	Major		Inter Info	[2]
D1083		Mogamulizumab	NA	NA	Major		Inter Info	[2]
D1085		Monomethyl fumarate	C5H6O4	5369209	Major		Inter Info	[2]
D1093		Muromonab	NA	NA	Major		Inter Info	[2]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[2]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[2]
D1111		Natalizumab	NA	NA	Major		Inter Info	[14]
D1118		Nelarabine	C11H15N5O5	3011155	Major		Inter Info	[2]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[2]
D1140		Niraparib	C19H20N4O	24958200	Major		Inter Info	[2]
D1161		Obinutuzumab	NA	NA	Major		Inter Info	[2]
D1162		Ocrelizumab	NA	NA	Major		Inter Info	[2]
D1164		Ofatumumab	NA	NA	Major		Inter Info	[2]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[2]
D1168		Olaratumab	NA	NA	Major		Inter Info	[2]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[2]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[2]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[2]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1], [15]
D1212		Paclitaxel	C47H51NO14	36314	Major		Inter Info	[2]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Major		Inter Info	[2]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[2]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[2]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[2]
D1234		Pegaspargase	C14H19NO	436058	Major		Inter Info	[2]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[2]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[2]
D1241		Pemetrexed	C20H21N5O6	135410875	Major		Inter Info	[2]
D1250		Pentostatin	C11H16N4O4	439693	Major		Inter Info	[2]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[2]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[2]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[2]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[2]
D1332		Prednisolone	C21H28O5	5755	Major		Inter Info	[2]
D1334		Prednisone	C21H26O5	5865	Major		Inter Info	[2]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[2]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[2]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[2]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[2]
D1403		Rilonacept	NA	NA	Major		Inter Info	[2]
D1410		Risankizumab	NA	NA	Major		Inter Info	[2]
D1416		Rituximab	NA	NA	Major		Inter Info	[1], [2]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[2]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[2]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[2]
D1447		Sarilumab	NA	NA	Major		Inter Info	[1], [2]
D1454		Secukinumab	NA	NA	Major		Inter Info	[2]
D1458		Selinexor	C17H11F6N7O	71481097	Major		Inter Info	[2]
D1467		Siltuximab	NA	NA	Major		Inter Info	[2]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[9], [17]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[2]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[2]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[2]
D1529		Tafasitamab	NA	NA	Major		Inter Info	[2]
D1532		Talazoparib	C19H14F2N6O	135565082	Major		Inter Info	[2]
D1548		Temozolomide	C6H6N6O2	5394	Major		Inter Info	[2]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[2]
D1551		Teniposide	C32H32O13S	452548	Major		Inter Info	[2]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[21], [22]
D1563		Tetracosactide	C136H210N40O31S	16133802	Major		Inter Info	[2]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[2]
D1575		Thiotepa	C6H12N3PS	5453	Major		Inter Info	[2]
D1583		Tildrakizumab	NA	NA	Major		Inter Info	[2]
D1589		Tioguanine	C5H5N5S	2723601	Major		Inter Info	[2]
D1594		Tisagenlecleucel	NA	NA	Major		Inter Info	[2]
D1599		Tocilizumab	NA	NA	Major		Inter Info	[1], [2]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[2]
D1610		Topotecan	C23H23N3O5	60700	Major		Inter Info	[2]
D1613		Tositumomab	NA	NA	Major		Inter Info	[2]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[2]
D1621		Trastuzumab	NA	NA	Major		Inter Info	[2]
D1622		Trastuzumab deruxtecan	NA	NA	Major		Inter Info	[2]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[2]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Major		Inter Info	[2]
D1639		Trifluridine	C10H11F3N2O5	6256	Major		Inter Info	[2]
D1646		Trimetrexate	C19H23N5O3	5583	Major		Inter Info	[2]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2]
D0150		Belantamab mafodotin	NA	NA	Major		Inter Info	[2]
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[2]
D0939		Lisocabtagene maraleucel	NA	NA	Major		Inter Info	[2]
D1113		Naxitamab	NA	NA	Major		Inter Info	[2]
D1448		Satralizumab	NA	NA	Major		Inter Info	[1], [2]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Major		Inter Info	[2]
D1671		Ustekinumab	NA	NA	Major		Inter Info	[2]
D1685		Vedolizumab	NA	NA	Major		Inter Info	[2]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[2]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[2]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[2]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[2]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[2]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[2]
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[2]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[34]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[45]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[1], [46]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[47]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[9], [1], [50]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [7], [8]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[9], [10], [11]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[16]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[9], [1], [37], [38]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[9], [1], [37], [38]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[3], [4], [5]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[3], [4], [5]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[3], [4], [5]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[3], [4], [5]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[3], [4], [5]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[18], [9], [19]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[20]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[3], [4], [5]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[3], [4], [5]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[18], [24], [25]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[18], [24], [25]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[18], [24], [25]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[18], [24], [25]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[18], [24], [25]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[18], [24], [25]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[41]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[18], [24], [25]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[18], [24], [25]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[18], [24], [25]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[18], [24], [25]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[52], [18], [9], [53], [54], [55], [24], [56], [57], [58], [25]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[18], [24], [25]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[26], [27], [28]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[26], [27], [28]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[29], [30], [31]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[29], [30], [31]
	Antagonize the effects of immunosuppressants					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[66], [67], [68]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[66], [67], [68]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[66], [67], [68]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[66], [67], [68]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[66], [67], [68]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
3	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
4	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
5	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
6	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
7	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
8	Canadian Pharmacists Association "e-CPS."
9	Cerner Multum, Inc. "Australian Product Information.".
10	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
11	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
12	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
13	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
14	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
15	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
16	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
17	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
18	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
19	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
20	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
21	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
22	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
23	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
24	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
25	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
26	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
27	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
28	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
29	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
30	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
31	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
32	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
33	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
34	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
35	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
36	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
37	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
38	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
39	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
40	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
41	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
42	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
43	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
44	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
45	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
46	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
47	AnazaoHealth Corporation "P32 Sodium Phosphate."
48	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
49	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
50	Multum Information Services, Inc. Expert Review Panel.
51	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
52	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
53	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
54	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
55	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
56	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
57	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
58	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
59	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
60	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
61	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
62	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
63	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
64	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
65	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
66	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
67	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
68	Pepping J "Echinacea." Am J Health Syst Pharm 56 (1999): 121-2

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