Drug General Information (ID: DDISCTKFD2)
Drug Name			Donepezil		Drug Info		Salicylic acid (sodium)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cholinesterase Inhibitors				Antiinflammatory Agents
Structure

Mechanism of Donepezil-Salicylic acid (sodium) Interaction (Severity Level: Minor)
Increased risk of GI mucosal injury/bleeding risk Click to Show/Hide Mechanism Graph
Drug Name		Donepezil				Salicylic acid (sodium)
Mechanism		GI mucosal injury/bleeding risk				GI mucosal injury/bleeding risk
Key Mechanism Factor 1
		Factor Name		Gastrointestinal toxicity
		Factor Description		The risk and severity of gastrointestinal toxicity, including inflammation, bleeding, ulceration, and perforation, increases when drugs with gastrointestinal mucosal irritant effects are combined.
Mechanism Description		Increased risk of GI mucosal injury/bleeding risk by the combination of Donepezil and Salicylic acid (sodium)

References
1	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.