Drug General Information (ID: DDIS8XM2QW)
Drug Name			Iodine		Drug Info		Iodide I-131		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Nutritional Supplements				Radiopharmaceuticals
Structure

Mechanism of Iodine-Iodide I-131 Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Iodine				Iodide I-131
Mechanism		Interfere with the therapeutic effect and/or diagnostic result of radioiodides				Radioiodide
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Iodide I-131 by Iodine

Recommended Action
Management		Iodine preparations including expectorants, vitamins, topicals, and intravascular iodine-containing contrast media should be withheld for at least 2 to 4 weeks and possibly longer, and cholecystographic agents should be withheld for more than 4 weeks, prior to administration of sodium iodide I-131 or I-123.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
3	Product Information. Visipaque (iodixanol). Nycomed Inc, Princeton, NJ.