Drug General Information (ID: DDIRM5T6E3)
Drug Name			Metyrosine		Drug Info		Ethanol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Analgesics
Structure

Mechanism of Metyrosine-Ethanol Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Metyrosine				Ethanol
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Metyrosine and Ethanol

Recommended Action
Management		The patient should be informed to use caution if these agents are coadministered, especially if performing hazardous tasks such as driving or operating machinery.

References
1	Product Information. Demser (metyrosine). Merck &amp Co, Inc, West Point, PA.