Drug General Information (ID: DDIRHM5KL1)
Drug Name			Diclofenac		Drug Info		Ethanol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Nsaids/Analgesics				Analgesics
Structure

Mechanism of Diclofenac-Ethanol Interaction (Severity Level: Moderate)
Increased risk of GI mucosal injury/bleeding risk Click to Show/Hide Mechanism Graph
Drug Name		Diclofenac				Ethanol
Mechanism		GI mucosal injury/bleeding risk				GI mucosal injury/bleeding risk
Key Mechanism Factor 1
		Factor Name		Gastrointestinal toxicity
		Factor Description		The risk and severity of gastrointestinal toxicity, including inflammation, bleeding, ulceration, and perforation, increases when drugs with gastrointestinal mucosal irritant effects are combined.
Mechanism Description		Increased risk of GI mucosal injury/bleeding risk by the combination of Diclofenac and Ethanol

Recommended Action
Management		Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References
1	Product Information. Motrin (ibuprofen). Pharmacia and Upjohn, Kalamazoo, MI.