Drug General Information (ID: DDIR9HWTZ6)
Drug Name			Methimazole		Drug Info		Thyroid, porcine		Drug Info
Drug Type		Small molecule				Hormones
Therapeutic Class		Antithyroid Agents				Thyroid Drugs

Mechanism of Methimazole-Thyroid, porcine Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Methimazole				Thyroid, porcine
Mechanism		Antithyroid agent				Thyroid hormone
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Methimazole when combined with Thyroid, porcine

Recommended Action
Management		Concomitant use of antithyroid agents and thyroid hormones should generally be avoided due to mutually negating effects.

References
1	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
2	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]