Drug General Information (ID: DDIQUYFEW3)
Drug Name			Vasopressin		Drug Info		Mecamylamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Antihypertensive Agents
Structure

Mechanism of Vasopressin-Mecamylamine Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Vasopressin				Mecamylamine
Mechanism		Vasopressin				Increase the effect of vasopressin on mean arterial blood pressure
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Vasopressin and Mecamylamine

Recommended Action
Management		Hemodynamic monitoring is recommended and the dose of vasopressin should be adjusted accordingly if concomitantly used with ganglionic blocking agents.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Vasopressin (vasopressin). APP (Abraxis Pharmaceutical Products), Schaumberg, IL.