Drug General Information (ID: DDIQNE219I)
Drug Name			Dasatinib		Drug Info		Magnesium hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antacids/Laxatives
Structure

Mechanism of Dasatinib-Magnesium hydroxide Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Dasatinib				Magnesium hydroxide
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Dasatinib due to altered gastric pH caused by Magnesium hydroxide

Recommended Action
Management		Patients treated with dasatinib should avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or paediatric oral solution) for at least two hours before and two hours after administration of dasatinib.

References
1	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.