Drug General Information (ID: DDIQKEX8DC)
Drug Name			Deferasirox		Drug Info		Aluminum hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Chelating Agents				Antacids
Structure

Mechanism of Deferasirox-Aluminum hydroxide Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Deferasirox				Aluminum hydroxide
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Aluminum hydroxide due to formation of complexes caused by Deferasirox

Recommended Action
Management		Deferasirox should not be taken with aluminum-containing preparations.

References
1	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.