Drug General Information (ID: DDIPYOAHL8)
Drug Name			Rilpivirine		Drug Info		Magnesium hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antacids/Laxatives
Structure

Mechanism of Rilpivirine-Magnesium hydroxide Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Rilpivirine				Magnesium hydroxide
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Rilpivirine due to altered gastric pH caused by Magnesium hydroxide

Recommended Action
Management		To minimize the risk of reduced viral susceptibility and resistance development associated with subtherapeutic levels of rilpivirine, antacids or other medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) should be administered at least 2 hours before or 4 hours after the rilpivirine dose.

References
1	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.