Drug General Information (ID: DDIPUS1J48)
Drug Name			Zonisamide		Drug Info		Levacetylmethadol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Analgesics
Structure

Mechanism of Zonisamide-Levacetylmethadol Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Zonisamide				Levacetylmethadol
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Zonisamide and Levacetylmethadol

Recommended Action
Management		Caution and dosage adjustments are advisable if CNS depressants are prescribed to patients on levomethadyl acetate maintenance. Alcohol use should be avoided, and patients should be advised to avoid driving, operating machinery, or engaging in potentially hazardous activities requiring mental alertness and motor coordination until they know how the medications affect them. Patients who are known to abuse sedatives, tranquilizers, antidepressants, benzodiazepines, and alcohol should be warned of the risk of serious and potentially fatal overdose if these substances are taken concurrently.

References
1	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
2	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.