Details of Drug

Drug General Information (ID: D1730)
Drug Name	Zonisamide
Drug Type	Small molecule
Drug Synonymous	Exceglan; Excegram; Excegran; Tremode; Trerief; Zonegran; Zonisamida; Zonisamidum; Elan brand of zonisamide; Zonisamida [Spanish]; Zonisamide monosodium; Zonisamidum [Latin]; AD 810; PD 110843; SPR_2; AD-810; AD-810N; E-2090; Excegran (TN); PD-110843; Zonegran (TN); Zonegran, Zonisamide; Zonisamide (ZNS); Zonisamide (JAN/USAN/INN); Zonisamide [USAN:BAN:INN:JAN]; 1,2-Benzisoxazole-3-methanesulfonamide; 1,2-benzoxazol-3-ylmethanesulfonamide; 1-(1,2-Benzoxazol-3-Yl)methanesulfonamide; 1-(1,2-benzisoxazol-3-yl)methanesulfonamide; 3-(Sulfamoylmethyl)-1,2-benzisoxazole; 3-sulfamoylmethyl-1,2-benzisoxazole Click to Show/Hide
Disease Class	8A61-8A6Z: Epilepsy/seizure
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C8H8N2O3S
InChI	1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
InChIKey	UBQNRHZMVUUOMG-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
External Link
	Pubchem ID	5734
	CAS Number	68291-97-4
	TTD ID	D09ZIS
	INTEDE ID	DR1737

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM038 Additive CNS depression effects BM061 Increased risk of hyperpyrexia BM070 Increased risk of metabolic acidosis BM087 Antagonize the effect of antiepileptic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Zonisamide
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 62
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[35], [3]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[35], [3]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[35], [3]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[35], [3]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[35], [3]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[67]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[35], [3]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[35], [3]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[35], [3]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[35], [3]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[35], [3]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[70]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[35], [3]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[44], [40], [77], [78]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[35], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[35], [3]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[35], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[44], [40], [84]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[35], [3]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[85]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[35], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[35], [3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[35], [3]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[35], [3]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[35], [3]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[35], [3]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[35], [3], [4]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[35], [3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[88]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[89], [90]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[35], [3]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[35], [3]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[35], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[35], [3]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[94], [95]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[35], [3], [4]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[96]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[35], [3]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[35], [3]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[35], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[35], [3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[100]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[35], [3]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[102]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[35], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[35], [3]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[35], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[35], [3]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[35], [3], [4]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[35], [3]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[103]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[35], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[35], [3]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[35], [3]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[35], [3]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[35], [3]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[35], [3]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[35], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[105], [106]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[35], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[35], [3]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[35], [3]
	CYP450 enzyme induction					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[35], [3]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[38]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[35], [3]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[35], [3]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[35], [3]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[35], [3]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[35], [76], [3]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[35], [3]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[35], [3]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[35], [3]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[35], [3]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[35], [3]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[35], [3]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[35], [3]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[35], [3]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[35], [3]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[35], [3]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[35], [3]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[44], [40], [82]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[35], [3]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[35], [3]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[35], [3]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[87]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[35], [3]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[35], [3]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[35], [3]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[44], [91]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[35], [3]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[93]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[35], [3]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[35], [3]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[35], [3]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[35], [3]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[35], [3]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[35], [76], [3]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[35], [3]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[44], [40], [82]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[44], [40], [104], [82]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[35], [3]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[35], [3]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[35], [3]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[40], [107]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[35], [3]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[109], [110], [111], [112], [113]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[109], [110], [111], [112], [113]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[80], [81]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[80], [81]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[80], [81]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 207
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[3]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[3]
D0123		Atropine	C17H23NO3	174174	Major		Inter Info	[3]
D0135		Azatadine	C20H22N2	19861	Major		Inter Info	[3]
D0160		Benzatropine	C21H25NO	1201549	Major		Inter Info	[3], [4], [5]
D0183		Biperiden	C21H29NO	2381	Major		Inter Info	[3]
D0214		Brompheniramine	C16H19BrN2	6834	Major		Inter Info	[3]
D0259		Carbinoxamine	C16H19ClN2O	2564	Major		Inter Info	[3]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[3]
D0351		Clemastine	C21H26ClNO	26987	Major		Inter Info	[3]
D0353		Clidinium	C22H26NO3+	2784	Major		Inter Info	[3]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[3]
D0403		Cyproheptadine	C21H21N	2913	Major		Inter Info	[3]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[3]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Major		Inter Info	[3]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[6], [7], [8]
D0482		Dicyclomine	C19H35NO2	3042	Major		Inter Info	[3]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[3]
D0532		Doxylamine	C17H22N2O	3162	Major		Inter Info	[3]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[3]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[3]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[3]
D0782		Hyoscyamine	C17H23NO3	154417	Major		Inter Info	[3]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[3]
D0957		Loxapine	C18H18ClN3O	3964	Major		Inter Info	[3]
D0987		Meclizine	C25H27ClN2	4034	Major		Inter Info	[3]
D1019		Methdilazine	C18H20N2S	14677	Major		Inter Info	[3]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[3]
D1166		Olanzapine	C17H20N4S	135398745	Major		Inter Info	[3]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[3]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[3]
D1347		Procyclidine	C19H29NO	4919	Major		Inter Info	[3]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[3]
D1354		Propantheline	C23H30NO3+	4934	Major		Inter Info	[3]
D1355		Propiomazine	C20H24N2OS	4940	Major		Inter Info	[3]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[3]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[3]
D1450		Scopolamine	C17H21NO4	3000322	Major		Inter Info	[3]
D1572		Thiethylperazine	C22H29N3S2	5440	Major		Inter Info	[3]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[3]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[3]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[3]
D1641		Trihexyphenidyl	C20H31NO	5572	Major		Inter Info	[3]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[3]
D1649		Tripelennamine	C16H21N3	5587	Major		Inter Info	[3]
D1650		Triprolidine	C19H22N2	5282443	Major		Inter Info	[3]
D1656		Trospium	C25H30NO3+	5284632	Major		Inter Info	[3]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[3]
D0020		Acrivastine	C22H24N2O2	5284514	Major		Inter Info	[3]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[3], [4], [5]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Major		Inter Info	[3]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[3]
D0154		Belladonna	C34H42N2O4	265028	Major		Inter Info	[3]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[3]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[3]
D0316		Chlorcyclizine	C18H21ClN2	2710	Major		Inter Info	[3]
D0323		Chlorpheniramine	C16H19ClN2	2725	Major		Inter Info	[3]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[3]
D0397		Cyclizine	C18H22N2	6726	Major		Inter Info	[3]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[3]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[3]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Major		Inter Info	[3]
D0502		Diphenhydramine	C17H21NO	3100	Major		Inter Info	[3]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[3]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[3], [4], [5]
D0662		Flavoxate	C24H25NO4	3354	Major		Inter Info	[3]
D0733		Glycopyrronium	C19H28NO3+	3494	Major		Inter Info	[3], [4], [5]
D0759		Homatropine	C16H21NO3	5282593	Major		Inter Info	[3], [4], [5]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[3]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[28], [29]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[3]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[3]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[3]
D1000		Mepenzolate	C21H26NO3+	4057	Major		Inter Info	[3]
D1006		Mepyramine	C17H23N3O	4992	Major		Inter Info	[3], [4], [5]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[3]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[3]
D1031		Methscopolamine	C18H24NO4+	71183	Major		Inter Info	[3]
D1084		Molindone	C16H24N2O2	23897	Major		Inter Info	[3]
D1188		Orphenadrine	C18H23NO	4601	Major		Inter Info	[3]
D1202		Oxybutynin	C22H31NO3	4634	Major		Inter Info	[3]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[3]
D1264		Phenindamine	C19H19N	11291	Major		Inter Info	[3]
D1282		Phenyltoloxamine	C17H21NO	7077	Major		Inter Info	[3], [4], [5]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[3]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[3]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[30], [31]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[3]
D1576		Thiothixene	C23H29N3O2S2	941651	Major		Inter Info	[3]
D1607		Tolterodine	C22H31NO	443879	Major		Inter Info	[3]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[32], [33], [34]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[32], [33], [34]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[36], [37]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[32], [33], [34]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[39], [40], [41]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[39], [40], [41]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[32], [33], [34]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[32], [33], [34]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[32], [33], [34]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[42], [43]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[32], [33], [34]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[32], [33], [34]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[32], [33], [34]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[32], [33], [34]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[32], [33], [34]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[32], [33], [34]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[32], [33], [34]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[32], [33], [34]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[32], [33], [34]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[32], [33], [34]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[32], [33], [34]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[32], [33], [34]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[32], [33], [34]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[4], [68], [69], [40], [5]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[32], [33], [34]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[32], [33], [34]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[32], [33], [34]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[32], [33], [34]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[32], [33], [34]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[32], [33], [34]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[71], [72], [73], [74], [75]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[32], [33], [34]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[32], [33], [34]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[32], [33], [34]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[32], [33], [34]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[32], [33], [34]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[32], [33], [34]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[32], [33], [34]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[32], [33], [34]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[32], [33], [34]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[32], [33], [34]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[4], [79], [5]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[32], [33], [34]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[32], [33], [34]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[32], [33], [34]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[32], [33], [34]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[32], [33], [34]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[32], [33], [34]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[32], [33], [34]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[32], [33], [34]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[32], [33], [34]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[32], [33], [34]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[32], [33], [34]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[32], [33], [34]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[83]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[32], [33], [34]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[32], [33], [34]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[32], [33], [34]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[32], [33], [34]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[32], [33], [34]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[32], [33], [34]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[32], [33], [34]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[32], [33], [34]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[39], [40], [41]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[32], [33], [34]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[32], [33], [34]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[86]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[32], [33], [34]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[32], [33], [34]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[32], [33], [34]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[32], [33], [34]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[32], [33], [34]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[32], [33], [34]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[32], [33], [34]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[32], [33], [34]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[32], [33], [34]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[32], [33], [34]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[44], [92]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[32], [33], [34]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[32], [33], [34]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[32], [33], [34]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[28]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[32], [33], [34]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[32], [33], [34]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[32], [33], [34]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[32], [33], [34]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[101]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[32], [33], [34]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[42], [43]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[32], [33], [34]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[32], [33], [34]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[32], [33], [34]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[32], [33], [34]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[32], [33], [34]
D1183		Opium	NA	NA	Moderate		Inter Info	[32], [33], [34]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[32], [33], [34]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[32], [33], [34]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[32], [33], [34]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[32], [33], [34]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[32], [33], [34]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[32], [33], [34]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[32], [33], [34]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[32], [33], [34]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[32], [33], [34]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[32], [33], [34]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[32], [33], [34]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[32], [33], [34]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[32], [33], [34]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[32], [33], [34]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[108]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[32], [33], [34]
D1675		Valerian	NA	NA	Moderate		Inter Info	[32], [33], [34]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[32], [33], [34]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[32], [33], [34]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[32], [33], [34]
	Increased risk of metabolic acidosis					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Major		Inter Info	[1], [2], [3]
D1015		Metformin	C4H11N5	4091	Major		Inter Info	[9], [10], [11]
D1018		Methazolamide	C5H8N4O3S2	4100	Major		Inter Info	[1], [2], [3]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[1], [2], [3]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Major		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[44], [40], [45], [46], [47]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[44], [40], [45], [46], [47]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [40], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[97], [98], [99]

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