Drug General Information (ID: DDIPHLZRD5)
Drug Name			Estrone sulfate		Drug Info		Hyaluronidase		Drug Info
Drug Type		Small molecule				Protein/peptide
Therapeutic Class		Estrogens				Absorption Enhancers
Structure

Mechanism of Estrone sulfate-Hyaluronidase Interaction (Severity Level: Minor)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Estrone sulfate				Hyaluronidase
Mechanism		Render tissues partially resistant to the dispersing action of hyaluronidase				Hyaluronidase
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Hyaluronidase when combined with Estrone sulfate

References
1	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
2	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
3	Product Information. Vitrase (hyaluronidase). Bausch and Lomb, Rochester, NY.