Drug General Information (ID: DDIPGEY24W)
Drug Name			Agalsidase beta		Drug Info		Gentamicin		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Metabolic Agents				Antibiotics
Structure

Mechanism of Agalsidase beta-Gentamicin Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Agalsidase beta				Gentamicin
Mechanism		Agalsidase beta				Reduce the pharmacological effect of aglyconidase
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Agalsidase beta when combined with Gentamicin

Recommended Action
Management		Agalsidase should not be coadministered with amiodarone, chloroquine, or gentamicin.

References
1	Product Information. Replagal (agalsidase alfa). Transkaryotic Therapies Inc, Cambridge, MA.