Drug General Information (ID: DDIPDLCYA0)
Drug Name			Sucralfate		Drug Info		Digoxin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Antiarrhythmic Agents
Structure

Mechanism of Sucralfate-Digoxin Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Digoxin
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Digoxin

Recommended Action
Management		Digitalis should be administered at least two hours before or 6 hours after sucralfate. Patients should be advised to notify their doctor if they experience worsening of their heart symptoms.

References
1	McCarthy DM "Sucralfate." N Engl J Med 325 (1991): 1017-25. [PMID: 1886624]
2	Product Information. Carafate (sucralfate). Hoechst Marion-Roussel Inc, Kansas City, MO.
3	Rey AM, Gums JG "Altered absorption of digoxin, sustained-release quinidine, and warfarin with sucralfate administration." DICP 25 (1991): 745-6. [PMID: 1949932]