Drug General Information (ID: DDIPC2HBA6)
  Drug Name Agalsidase beta Drug Info Amiodarone Drug Info
  Drug Type Protein/peptide Small molecule
  Therapeutic Class Metabolic Agents Antiarrhythmic Agents
  Structure

 Mechanism of Agalsidase beta-Amiodarone Interaction (Severity Level: Major)
     Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Agalsidase beta Amiodarone
      Mechanism Agalsidase beta Reduce the pharmacological effect of aglyconidase
      Key Mechanism Factor 1
Factor Name Pharmacodynamics
Factor Description Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
      Mechanism Description
  • Attenuated pharmacological effects of  Agalsidase beta when combined with Amiodarone 

Recommended Action
      Management Agalsidase should not be coadministered with amiodarone, chloroquine, or gentamicin.

References
1 Product Information. Replagal (agalsidase alfa). Transkaryotic Therapies Inc, Cambridge, MA.