Drug General Information (ID: DDIP2MH41N)
Drug Name			Sucralfate		Drug Info		Naproxen		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Nsaids/Analgesics
Structure

Mechanism of Sucralfate-Naproxen Interaction (Severity Level: Minor)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Naproxen
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Naproxen

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Naprosyn (naproxen). Syntex Laboratories Inc, Palo Alto, CA.