Drug General Information (ID: DDIOZN8XWV)
Drug Name			Tuberculin purified protein derivative		Drug Info		Typhoid vaccine (live)		Drug Info
Drug Type		Allergenics				Vaccine
Therapeutic Class		Allergy Test				Vaccine

Mechanism of Tuberculin purified protein derivative-Typhoid vaccine (live) Interaction (Severity Level: Moderate)
Diminish the response to diagnostic skin test antigens Click to Show/Hide Mechanism Graph
Drug Name		Tuberculin purified protein derivative				Typhoid vaccine (live)
Mechanism		Diagnostic skin test antigens				Vaccine or toxoid
Key Mechanism Factor 1
		Factor Name		Diagnostic skin test antigens
		Factor Description		The efficacy of diagnostic skin test antigens may be reduced, leading to falsely insignificant or false-negative results may occur in such patients.
Mechanism Description		Reduced reactions to diagnostic skin test antigens for Tuberculin purified protein derivative when combined with Typhoid vaccine (live)

Recommended Action
Management		Clinicians should be aware of the potential for falsely insignificant or false-negative results when performing delayed-hypersensitivity skin testing on patients who have recently received live virus vaccines. Diagnostic skin test antigens should be administered before, simultaneously with, or 4 to 6 weeks after immunization.

References
1	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
2	Product Information. Multitest CMI (skin test antigens, multiple). Aventis Pharmaceuticals, Swiftwater, PA.
3	Product Information. MSTA Mumps Skin Test Antigen (mumps skin test antigen). Aventis Pharmaceuticals, Swiftwater, PA.