Drug General Information (ID: DDIOTUD9PK)
Drug Name			Ruxolitinib		Drug Info		Lactobacillus acidophilus		Drug Info
Drug Type		Small molecule				Probiotic
Therapeutic Class		Multikinase Inhibitors				Flora Modifiers

Mechanism of Ruxolitinib-Lactobacillus acidophilus Interaction (Severity Level: Moderate)
Antagonize the effect of probiotics Click to Show/Hide Mechanism Graph
Drug Name		Ruxolitinib				Lactobacillus acidophilus
Mechanism		Immunosuppressive effects				Probiotic
Key Mechanism Factor 1
		Factor Name		Probiotics
		Factor Description		Probiotics are a combination of live beneficial bacteria and/or yeasts that naturally live in your body. Probiotics are made up of good bacteria that helps keep your body healthy and working well. This good bacteria helps you in many ways, including fighting off bad bacteria when you have too much of it, helping you feel better.
Mechanism Description		Antagonize the effect of Lactobacillus acidophilus when combined with Ruxolitinib

Recommended Action
Management		Caution is advised when probiotics are used during immunosuppressant or intense antineoplastic therapy. It may be advisable to avoid using probiotics, particularly products containing saccharomyces boulardii, in patients who are significantly immunosuppressed.

References
1	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
2	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
3	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]