Details of Drug

Drug General Information (ID: D1434)
Drug Name	Ruxolitinib
Drug Type	Small molecule
Drug Synonymous	Ruxolitinib (JAK inhibitor) Click to Show/Hide
Disease Class	2A20: Myeloproliferative neoplasm; 2C10: Pancreatic cancer; 3B63: Thrombocytosis; EA80: Atopic eczema; ED63: Acquired hypomelanotic disorder
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C17H18N6
InChI	1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
InChIKey	HFNKQEVNSGCOJV-OAHLLOKOSA-N
Canonical SMILES	C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
External Link
	Pubchem ID	25126798
	CAS Number	941678-49-5
	CHEBI ID	66919
	TTD ID	D04LKS

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ruxolitinib
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 71
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[7]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[8], [7]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[7]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[125]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[136]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[8], [7]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[8], [7]
D0100		Aprepitant	C23H21F7N4O3	135413536	Minor		Inter Info	[8], [7]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[8], [7]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[8], [7]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[8], [7]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[8], [7]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[8], [7]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Minor		Inter Info	[8], [7]
D0413		Dalfopristin	C34H50N4O9S	6323289	Minor		Inter Info	[8], [7]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[8], [7]
D0426		Darunavir	C27H37N3O7S	213039	Minor		Inter Info	[8], [7]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[8], [7]
D0534		Dronedarone	C31H44N2O5S	208898	Minor		Inter Info	[8], [7]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[8], [7]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Minor		Inter Info	[8], [7]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[8], [7]
D0793		Imatinib	C29H31N7O	5291	Minor		Inter Info	[8], [7]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Minor		Inter Info	[8], [7]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[8], [7]
D0891		Lanreotide	C54H69N11O10S2	71349	Minor		Inter Info	[8], [7]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[8], [7]
D0944		Lomitapide	C39H37F6N3O2	9853053	Minor		Inter Info	[8], [7]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[8], [7]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[8], [7]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[8], [7]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[8], [7]
D1163		Octreotide	C49H66N10O10S2	448601	Minor		Inter Info	[8], [7]
D1232		Pazopanib	C21H23N7O2S	10113978	Minor		Inter Info	[8], [7]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[8], [7]
D0171		Berotralstat	C30H26F4N6O	137528262	Minor		Inter Info	[8], [7]
D0543		Duvelisib	C22H17ClN6O	50905713	Minor		Inter Info	[8], [7]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[8], [7]
D0638		Fedratinib	C27H36N6O3S	16722836	Minor		Inter Info	[8], [7]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[8], [7]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Minor		Inter Info	[8], [7]
D0906		Letermovir	C29H28F4N4O4	45138674	Minor		Inter Info	[8], [7]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[8], [7]
D1214		Palbociclib	C24H29N7O2	5330286	Minor		Inter Info	[8], [7]
D1398		Ribociclib	C23H30N8O	44631912	Minor		Inter Info	[8], [7]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[8], [7]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[8], [7]
D1505		Stiripentol	C14H18O3	5311454	Minor		Inter Info	[8], [7]
D1524		Suvorexant	C23H23ClN6O2	24965990	Minor		Inter Info	[8], [7]
D1709		Voxelotor	C19H19N3O3	71602803	Minor		Inter Info	[8], [7]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[8], [7]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[8], [7]
	CYP450 enzyme induction					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[7]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[7]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[7]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[7]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[7]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[7]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[7]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[7]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[7]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[7]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[7]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[7]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[7]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[7]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[7]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[7]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[7]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[7]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[7]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[7]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[7]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[7]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[7]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[7]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[7]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[7]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[24], [135]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[7]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[7]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[7]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[7]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[7]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[7]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[7]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[7]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[8], [150]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[7]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[7]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[7]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[7]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[7]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[155], [156], [157], [158], [159]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[155], [156], [157], [158], [159]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 85
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[8], [18]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[28]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[30], [31]
D1111		Natalizumab	NA	NA	Major		Inter Info	[32]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[24], [8], [43]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[8], [50]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[24], [54]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[30], [31]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[58]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[59]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[8], [62], [63]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[55], [64], [65]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[66]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[67], [68], [69]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[24], [8]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[8], [62], [63]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[8], [62], [63]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[8], [62], [63]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[67], [68], [69]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[8], [62], [63]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[8], [62], [63]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[8], [62], [63]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[8], [62], [63]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[8], [62], [63]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[8], [62], [63]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[8], [62], [63]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[8], [62], [63]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[8], [62], [63]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[8], [62], [63]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[8], [62], [63]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[111]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[8], [62], [63]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[8], [62], [63]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[8], [62], [63]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[113]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[8], [62], [63]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[8], [62], [63]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[8], [62], [63]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[8], [62], [63]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[8], [62], [63]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[8], [62], [63]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[8], [62], [63]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[8], [62], [63]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[8], [62], [63]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[8], [62], [63]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[8], [62], [63]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[8], [62], [63]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[8], [62], [63]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[8], [62], [63]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[8], [62], [63]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[8], [62], [63]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[8], [62], [63]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[8], [62], [63]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[121]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[8], [62], [63]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[8], [62], [63]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[67], [68], [69]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[8], [124]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[134]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[134]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[8], [62], [63]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[8], [62], [63]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[134]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[8], [62], [63]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[137]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[138]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[8], [139]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[147]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[148]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[24], [8], [149]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[8], [62], [63]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[8], [62], [63]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[8], [62], [63]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[8], [62], [63]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[8], [62], [63]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[152]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[153]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[8], [62], [63]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[8], [62], [63]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[24], [8], [154]
	Additive myelosuppressive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[8], [19], [20]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[24], [25], [26]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[24], [8], [117], [118]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[24], [8], [117], [118]
	Increased risk of bleeding					Drug Num: 73
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[8], [9]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[17]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16]
D0415		Danaparoid	NA	NA	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[21]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[22], [23]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[27]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[29]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[22], [33]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[24], [8], [34]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[8], [35]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[36]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[37]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[38]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[8], [39]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[44]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[45]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[46], [47], [8], [48]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[8], [22], [49]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[51]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[8], [52], [53]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[22]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16]
D1613		Tositumomab	NA	NA	Major		Inter Info	[60], [61]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[60], [61]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[70], [71], [72]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[70], [71], [72]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[22], [112]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[70], [71], [72]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[70], [71], [72]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[70], [71], [72]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[70], [71], [72]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[70], [71], [72]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[70], [71], [72]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[70], [71], [72]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[70], [71], [72]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[119]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[70], [71], [72]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[70], [71], [72]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[70], [71], [72]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[70], [71], [72]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[70], [71], [72]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[70], [71], [72]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[70], [71], [72]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[70], [71], [72]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[70], [71], [72]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[22], [123]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[70], [71], [72]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[70], [71], [72]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[70], [71], [72]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[70], [71], [72]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[8], [151]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[70], [71], [72]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[73], [74], [75], [76], [24], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110]
D0253		Capsicum	NA	NA	Minor		Inter Info	[160]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[160], [161], [162]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[40], [41], [42]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[40], [41], [42]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[40], [41], [42]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[40], [41], [42]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[40], [41], [42]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[55], [24], [56]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[57]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[40], [41], [42]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[40], [41], [42]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[40], [41], [42]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[120]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[55], [126], [127]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[55], [126], [127]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[55], [126], [127]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[55], [126], [127]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[55], [126], [127]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[55], [126], [127]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[55], [126], [127]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[140], [55], [24], [141], [142], [143], [126], [144], [145], [146], [127]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[55], [126], [127]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[55], [126], [127]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[55], [126], [127]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[128], [129], [130]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[128], [129], [130]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[131], [132], [133]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[131], [132], [133]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[131], [132], [133]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[131], [132], [133]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[114], [115], [116]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[22], [122]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[114], [115], [116]

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Enbrel (etanercept). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Product Information. Humira (adalimumab). Abbott Pharmaceutical, Abbott Park, IL.
4	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
5	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
6	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
7	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
8	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
10	Price AJ, Frcpath DO "Is there a clinical interaction between low molecular weight heparin and non-steroidal analgesics after total hip replacement?" Ann R Coll Surg Engl 77 (1995): 395. [PMID: 7486773]
11	Product Information. Arixtra (fondaparinux). Organon, West Orange, NJ.
12	Product Information. Fragmin (dalteparin). Pharmacia and Upjohn, Kalamazoo, MI.
13	Product Information. Innohep (tinzaparin) DuPont Pharmaceuticals, Wilmington, DE.
14	Product Information. Lovenox (enoxaparin). Rhone-Poulenc Rorer, Collegeville, PA.
15	Product Information. Normiflo (ardeparin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
16	Product Information. Orgaran (danaparoid). Organon, West Orange, NJ.
17	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
18	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
19	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
20	Canadian Pharmacists Association "e-CPS."
21	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
22	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
23	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
24	Cerner Multum, Inc. "Australian Product Information.".
25	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
26	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
27	Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
28	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
29	Product Information. In-111 Zevalin (ibritumomab). IDEC Pharmaceuticals Corporation, San Diego, CA.
30	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
31	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
32	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
33	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
34	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
35	Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
36	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
37	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
38	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
39	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
40	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
41	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
42	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
43	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
44	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
45	Product Information. Savaysa (edoxaban). Daiichi Sankyo, Inc., Parsippany, NJ.
46	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
47	Cerner Multum, Inc. "Canadian Product Information.".
48	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
49	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
50	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
51	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
52	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
53	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
54	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
55	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
56	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
57	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
58	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
59	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
60	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
61	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
62	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
63	Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.
64	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
65	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
66	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
67	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
68	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
69	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
70	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
71	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
72	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
73	Alderman CP, Moritz CK, Ben-Tovim DI "Abnormal platelet aggregation associated with fluoxetine therapy." Ann Pharmacother 26 (1992): 1517-9. [PMID: 1482806]
74	Alderman CP, Seshadri P, Ben-Tovim DI "Effects of serotonin reuptake inhibitors on hemostasis." Ann Pharmacother 30 (1996): 1232-4. [PMID: 8913401]
75	Aranth J, Lindberg C "Bleeding, a side effect of fluoxetine." Am J Psychiatry 149 (1992): 412. [PMID: 1536285]
76	Bannister SJ, Houser VP, Hulse JD, Kisicki JC, Rasmussen JG "Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin." Acta Psychiatr Scand Suppl 350 (1989): 102-6. [PMID: 2530759]
77	Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7. [PMID: 2198298]
78	Claire RJ, Servis ME, Cram DL Jr "Potential interaction between warfarin sodium and fluoxetine." Am J Psychiatry 148 (1991): 1604. [PMID: 1928485]
79	Dalton SO, Johansen C, Mellemkjaer L, Norgard B, Sorensen HT, Olsen JH "Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study." Arch Intern Med 163 (2003): 59-64. [PMID: 12523917]
80	de Abajo FJ, Jick H, Derby L, Jick S, Schmitz S "Intracranial haemorrhage and use of selective serotonin reuptake inhibitors." Br J Clin Pharmacol 50 (2000): 43-7. [PMID: 10886117]
81	de Abajo FJ, Rodriguez LA, Montero D "Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study." BMJ 319 (1999): 1106-9. [PMID: 10531103]
82	de Maistre E, Allart C, Lecompte T, Bollaert PE "Severe bleeding associated with use of low molecular weight heparin and selective serotonin reuptake inhibitors." Am J Med 113 (2002): 530-2. [PMID: 12427509]
83	Dent LA, Orrock MW "Warfarin-fluoxetine and diazepam-fluoxetine interaction." Pharmacotherapy 17 (1997): 170-2. [PMID: 9017779]
84	Ford MA, Anderson ML, Rindone JP, Jaskar DW "Lack of effect of fluoxetine on the hypoprothrombinemic response of warfarin." J Clin Psychopharmacol 17 (1997): 110-2. [PMID: 10950474]
85	Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B "Paroxetine decreases platelet serotonin storage and platelet function in human beings." Clin Pharmacol Ther 68 (2000): 435-42. [PMID: 11061584]
86	Humphries JE, Wheby MS, VandenBerg SR "Fluoxetine and the bleeding time." Arch Pathol Lab Med 114 (1990): 727-8. [PMID: 2363631]
87	Krivy J, Wiener J "Sertraline and platelet counts in idiopathic thrombocytopenia purpura." Lancet 345 (1995): 132. [PMID: 7815874]
88	Leung M, Shore R "Fluvoxamine-associated bleeding." Can J Psychiatry 41 (1996): 604-5. [PMID: 8946088]
89	Messiha FS "Fluoxetine - adverse effects and drug-drug interactions." J Toxicol Clin Toxicol 31 (1993): 603-30. [PMID: 8254702]
90	Ottervanger JP, Stricker BH, Huls J, Weeda JN "Bleeding attributed to the intake of paroxetine." Am J Psychiatry 151 (1994): 781-2. [PMID: 8166328]
91	Pai VB, Kelly MW "Bruising associated with the use of fluoxetine." Ann Pharmacother 30 (1996): 786-8. [PMID: 8826562]
92	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
93	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
94	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
95	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
96	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
97	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
98	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
99	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
100	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
101	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
102	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
103	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
104	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
105	Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30. [PMID: 9796863]
106	Skop BP, Brown TM "Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors." Psychosomatics 37 (1996): 12-6. [PMID: 8600488]
107	Woolfrey S, Gammack NS, Dewar MS, Brown PJ "Fluoxetine-warfarin interaction." BMJ 307 (1993): 241. [PMID: 8369688]
108	Yaryura-Tobias JA, Kirschen H, Ninan P, Mosberg HJ "Fluoxetine and bleeding in obsessive-compulsive disorder." Am J Psychiatry 148 (1991): 949. [PMID: 2053641]
109	Layton D, Clark DWJ, Pearce GL, Shakir SAW "Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England." Eur J Clin Pharmacol 57 (2001): 167-76. [PMID: 11417450]
110	Tata LJ, Fortun PJ, Hubbard RB, et al. "Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding?" Aliment Pharmacol Ther 22 (2005): 175-81. [PMID: 16091054]
111	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
112	Product Information. Kybella (deoxycholic acid). Kythera Biopharmaceuticals, Inc., Westlake Village, CA.
113	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
114	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
115	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
116	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
117	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
118	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
119	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.
120	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
121	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
122	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
123	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
124	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
125	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
126	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
127	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
128	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
129	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
130	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
131	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
132	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
133	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
134	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
135	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
136	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
137	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
138	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
139	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
140	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
141	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
142	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
143	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
144	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
145	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
146	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
147	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
148	AnazaoHealth Corporation "P32 Sodium Phosphate."
149	Multum Information Services, Inc. Expert Review Panel.
150	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
151	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
152	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
153	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
154	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
155	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
156	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
157	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
158	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
159	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
160	Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
161	Lambert JP, Cormier J "Potential interaction between warfarin and boldo-fenugreek." Pharmacotherapy 21 (2001): 509-12. [PMID: 11310527]
162	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence