Drug General Information (ID: DDIOST7DYJ)
Drug Name			Cyclosporine		Drug Info		Foscarnet		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antiviral Agents
Structure

Mechanism of Cyclosporine-Foscarnet Interaction (Severity Level: Major)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Foscarnet
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Cyclosporine and Foscarnet

Recommended Action
Management		The manufacturer recommends avoiding the concurrent use of other nephrotoxic drugs during foscarnet therapy. If these agents are used concomitantly, consider close observation of renal function and discontinue foscarnet treatment if needed.

References
1	Morales JM, Munoz MA, Zatarain GF, et al. "Reversible acute renal failure caused by the combined use of foscarnet and cyclosporin in organ transplanted patients." Nephrol Dial Transplant 10 (1995): 882-3. [PMID: 7566623]
2	Product Information. Foscavir (foscarnet). Astra USA, Westborough, MA.