Drug General Information (ID: DDIOSFQ43D)
Drug Name			Venlafaxine		Drug Info		Yohimbine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Mydriatics
Structure

Mechanism of Venlafaxine-Yohimbine Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Venlafaxine				Yohimbine
Mechanism		Potentiate the pressor effect of yohimbine				Yohimbine
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Venlafaxine and Yohimbine

Recommended Action
Management		Yohimbine should be avoided in patients undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of norepinephrine.

References
1	Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
2	Mansoor GA "Herbs and alternative therapies in the hypertension clinic." Am J Hypertens 14(9 Pt 1) (2001): 971-5
3	Product Information. Yocon (yohimbine). Glenwood Inc, Tenafly, NJ.