Details of Drug

Details of Drug

 Drug General Information (ID: D1713)
  Drug Name
Yohimbine
  Drug Type Small molecule
  Drug Synonymous
APHRODINE; Actibine; Aphrodyne; Aphrosol; Corynine; Johimbin; Quebrachin; Quebrachine; Thybine; Yocon; Yohimar; Yohimbin; Yohimex; Yoman; Yovital; Dayto himbin; Yohimbic acid methyl ester; Baron-X; Trans-Quinolizidine yohimbine; Yohimbine (DCF); Methyl 17alpha-hydroxyyohimban-16alpha-carboxylate; Yohimbol-16alpha-carboxylic acid, methyl ester (6CI); Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.; Methyl (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylate; Yohimban-16alpha-carboxylic acid, 17alpha-hydroxy-, methyl ester (8CI); Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy-, methyl ester; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-(9CI); Yohimban-16-.alpha.-carboxylic acid, 17-.alpha.-hydroxy-, methyl ester; (+)-Yohimbin; (+)-Yohimbine; (16alpha,17alpha)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester; (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester; 17-Hydroxy-yohimbane-16-carboxylic acid methyl ester; 17-Hydroxyyohimban-16-carboxylic acid methyl ester; 17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester; 2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
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  Disease Class HA00-HA01: Sexual dysfunction
  Therapeutic Class Mydriatics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C21H26N2O3
  InChI 1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
  InChIKey BLGXFZZNTVWLAY-SCYLSFHTSA-N
  Canonical SMILES COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
  External Link
Pubchem ID 8969
CAS Number 146-48-5
CHEBI ID 10093
TTD ID D0H4JM
INTEDE ID DR1722
VARIDT ID DR01191

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM014  Interference of cell/tissue uptake
BM022  CYP450 enzyme induction
BM041  Additive hypertensive effects
BM061  Increased risk of hyperpyrexia
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Yohimbine
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[1]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[7], [8], [9]
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  21
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[2], [3], [4]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[2], [3], [4]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[2], [3], [4]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[2], [3], [4]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[2], [3], [4]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[2], [3], [4]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[2], [3], [4]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[2], [5], [6]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[2], [5], [6]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Moderate    Inter Info   
[2], [3], [4]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[2], [3], [4]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[2], [3], [4]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[2], [5], [6]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[2], [5], [6]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[2], [3], [4]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[2], [5], [6]
D1455
 
Selegiline
 
C13H17N
 
26757 
Moderate    Inter Info   
[2], [5], [6]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[2], [5], [6]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[2], [3], [4]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[2], [3], [4]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Moderate    Inter Info   
[2], [3], [4]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0952
 
Lorcaserin
 
C11H14ClN
 
11658860 
Moderate    Inter Info   
[10]
References
1 Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
2 Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
3 Mansoor GA "Herbs and alternative therapies in the hypertension clinic." Am J Hypertens 14(9 Pt 1) (2001): 971-5
4 Product Information. Yocon (yohimbine). Glenwood Inc, Tenafly, NJ.
5 Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
6 Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
7 Fraser CG, Fierro L "Comment: troglitazone." Ann Pharmacother 32 (1998): 1111-2. [PMID: 9793612]
8 Park MH, Pelegrin D, Haug MT, Young JB "Troglitazone, a new antidiabetic agent, decreases cyclosporine level." J Heart Lung Transplant 17 (1998): 1139-40. [PMID: 9855455]
9 Product Information. Rezulin (troglitazone). Parke-Davis, Morris Plains, NJ.
10 Product Information. Belviq (lorcaserin). Eisai Inc, Teaneck, NJ.