Drug General Information (ID: DDIOEISMPF)
Drug Name			Vasopressin		Drug Info		Norepinephrine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Vasoconstrictor Agents
Structure

Mechanism of Vasopressin-Norepinephrine Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Vasopressin				Norepinephrine
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Vasopressin and Norepinephrine

Recommended Action
Management		The use of injectable vasopressin or large doses of intranasal or oral desmopressin with other pressor agents should only be done with careful hemodynamic monitoring. Vasopressin dosage may need to be adjusted. Consulting local protocols with respect to the dosage of vasopressin and the order of administration when used with noradrenaline is encouraged.

References
1	Product Information. DDAVP (desmopressin). Rhone-Poulenc Rorer, Collegeville, PA.
2	Product Information. Vasostrict (vasopressin). Par Pharmaceutical Inc, Chestnut Ridge, NY.
3	Russell JA, Walley KR, Singer J, et al. "Vasopressin versus norepinephrine infusion in patients with septic shock." N Engl J Med 358 (2008): 877-87