Drug General Information (ID: DDIO0WD95Q)
Drug Name			Tranylcypromine		Drug Info		Acrivastine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Antiinflammatory Agents
Structure

Mechanism of Tranylcypromine-Acrivastine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Tranylcypromine				Acrivastine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Tranylcypromine and Acrivastine

Recommended Action
Management		Prescribing antihistamines in combination with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, procarbazine) should generally be avoided. If concomitant treatment is unavoidable, patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References
1	Canadian Pharmacists Association.
2	Kahn DA "Possible toxic interaction between cyproheptadine and phenelzine." Am J Psychiatry 144 (1987): 1242-3. [PMID: 3631331]
3	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.