Drug General Information (ID: D0020)
  Drug Name
Acrivastine
  Drug Type Small molecule
  Drug Synonymous
Acrivastin; Acrivastina; Acrivastinum; Semprex; Acrivastina [Spanish]; Acrivastinum [Latin]; Benadryl allergy relief; BW 0270C; BW 825C; BW A825C; BW-825C; Acrivastine (USAN/INN); Acrivastine [USAN:INN:BAN]; E-(9CI); (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid; (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid; (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid; (E)-6-((E)-3-(1-Pyrrolidinyl-1-p-tolylpropenyl)-2-pyridinacrylsaeure; (E,E)-3-[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid; 3-{6-[1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid
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  Disease Class CA08: Vasomotor/allergic rhinitis
  Therapeutic Class Antiinflammatory Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C22H24N2O2
  InChI 1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
  InChIKey PWACSDKDOHSSQD-IUTFFREVSA-N
  Canonical SMILES CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC(=N3)C=CC(=O)O
  External Link
Pubchem ID 5284514
CAS Number 87848-99-5
CHEBI ID 83168
TTD ID D0O4EU
VARIDT ID DR01418

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM033  Additive anticholinergic effects
BM035  Additive antimotility effects
BM038  Additive CNS depression effects
BM054  Increased risk of GI mucosal injury/bleeding risk
BM061  Increased risk of hyperpyrexia
BM091  Antagonize the effect of cholinergic agents
BM106  Diminish the response to diagnostic skin test antigens
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Acrivastine
      Pharmacodynamic additive effects
   Additive anticholinergic effects Drug Num:  98
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0019
 
Aclidinium
 
C26H30NO4S2+
 
11434515 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26]
D0154
 
Belladonna
 
C34H42N2O4
 
265028 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1031
 
Methscopolamine
 
C18H24NO4+
 
71183 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1282
 
Phenyltoloxamine
 
C17H21NO
 
7077 
Moderate    Inter Info   
[32], [34], [40]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[32], [34], [40]
D0051
 
Amantadine
 
C10H17N
 
2130 
Moderate    Inter Info   
[50], [51]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0123
 
Atropine
 
C17H23NO3
 
174174 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0135
 
Azatadine
 
C20H22N2
 
19861 
Moderate    Inter Info   
[32], [34], [40]
D0160
 
Benzatropine
 
C21H25NO
 
1201549 
Moderate    Inter Info   
[32], [34], [40]
D0183
 
Biperiden
 
C21H29NO
 
2381 
Moderate    Inter Info   
[32], [34], [40]
D0196
 
Botulinum toxin type A
 
NA
 
NA
Moderate    Inter Info   
[56], [57], [58]
D0197
 
Botulinum Toxin Type B
 
NA
 
NA
Moderate    Inter Info   
[56], [57], [58]
D0202
 
Brexpiprazole
 
C25H27N3O2S
 
11978813 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0214
 
Brompheniramine
 
C16H19BrN2
 
6834 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0259
 
Carbinoxamine
 
C16H19ClN2O
 
2564 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0262
 
Cariprazine
 
C21H32Cl2N4O
 
11154555 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0316
 
Chlorcyclizine
 
C18H21ClN2
 
2710 
Moderate    Inter Info   
[32], [34], [40]
D0323
 
Chlorpheniramine
 
C16H19ClN2
 
2725 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0351
 
Clemastine
 
C21H26ClNO
 
26987 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0353
 
Clidinium
 
C22H26NO3+
 
2784 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0397
 
Cyclizine
 
C18H22N2
 
6726 
Moderate    Inter Info   
[32], [34], [40]
D0398
 
Cyclobenzaprine
 
C20H21N
 
2895 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0403
 
Cyproheptadine
 
C21H21N
 
2913 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0424
 
Darifenacin
 
C28H30N2O2
 
444031 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0456
 
Dexbrompheniramine
 
C16H19BrN2
 
16960 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0482
 
Dicyclomine
 
C19H35NO2
 
3042 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0498
 
Dimenhydrinate
 
C24H28ClN5O3
 
10660 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0502
 
Diphenhydramine
 
C17H21NO
 
3100 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[32], [34], [40]
D0532
 
Doxylamine
 
C17H22N2O
 
3162 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0655
 
Fesoterodine
 
C26H37NO3
 
6918558 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0662
 
Flavoxate
 
C24H25NO4
 
3354 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0733
 
Glycopyrronium
 
C19H28NO3+
 
3494 
Moderate    Inter Info   
[32], [34], [40]
D0734
 
Glycopyrronium (topical)
 
C19H28NO3+
 
3494 
Moderate    Inter Info   
[20], [22], [23]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0782
 
Hyoscyamine
 
C17H23NO3
 
154417 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0842
 
Ipratropium
 
C20H30NO3+
 
657309 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26]
D0957
 
Loxapine
 
C18H18ClN3O
 
3964 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0959
 
Lumateperone
 
C24H28FN3O
 
21302490 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0987
 
Meclizine
 
C25H27ClN2
 
4034 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0998
 
Memantine
 
C12H21N
 
4054 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1000
 
Mepenzolate
 
C21H26NO3+
 
4057 
Moderate    Inter Info   
[32], [34], [40]
D1006
 
Mepyramine
 
C17H23N3O
 
4992 
Moderate    Inter Info   
[32], [34], [40]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[32], [34], [40]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[32], [34], [40]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[32], [34], [40]
D1084
 
Molindone
 
C16H24N2O2
 
23897 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1188
 
Orphenadrine
 
C18H23NO
 
4601 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1202
 
Oxybutynin
 
C22H31NO3
 
4634 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1264
 
Phenindamine
 
C19H19N
 
11291 
Moderate    Inter Info   
[32], [34], [40]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1347
 
Procyclidine
 
C19H29NO
 
4919 
Moderate    Inter Info   
[32], [34], [40]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[32], [34], [40]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1354
 
Propantheline
 
C23H30NO3+
 
4934 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1355
 
Propiomazine
 
C20H24N2OS
 
4940 
Moderate    Inter Info   
[32], [34], [40]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1450
 
Scopolamine
 
C17H21NO4
 
3000322 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[32], [34], [40]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[32], [34], [40]
D1576
 
Thiothixene
 
C23H29N3O2S2
 
941651 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1590
 
Tiotropium
 
C19H22NO4S2+
 
5487427 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26]
D1607
 
Tolterodine
 
C22H31NO
 
443879 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[32], [34], [40]
D1641
 
Trihexyphenidyl
 
C20H31NO
 
5572 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1649
 
Tripelennamine
 
C16H21N3
 
5587 
Moderate    Inter Info   
[32], [34], [40]
D1650
 
Triprolidine
 
C19H22N2
 
5282443 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1656
 
Trospium
 
C25H30NO3+
 
5284632 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1665
 
Umeclidinium
 
C29H34NO2+
 
11519070 
Moderate    Inter Info   
[19], [20], [21], [22], [23], [24], [25], [26]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Moderate    Inter Info   
[27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D0843
 
Ipratropium (nasal)
 
C20H30NO3+
 
657309 
Minor    Inter Info   
[66], [84], [68]
   Additive antimotility effects Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0947
 
Loperamide
 
C29H33ClN2O2
 
3955 
Moderate    Inter Info   
[78]
   Additive CNS depression effects Drug Num:  19
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1485
 
Sodium oxybate
 
C4H7NaO3
 
23663870 
Major    Inter Info   
[13], [14]
D1609
 
Topiramate
 
C12H21NO8S
 
5284627 
Major    Inter Info   
[15]
D1730
 
Zonisamide
 
C8H8N2O3S
 
5734 
Major    Inter Info   
[16]
D0201
 
Brexanolone
 
C21H34O2
 
92786 
Moderate    Inter Info   
[42]
D0600
 
Esketamine
 
C13H16ClNO
 
182137 
Moderate    Inter Info   
[45], [46]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[47]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[52], [53]
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[54], [48], [55]
D0205
 
Brimonidine (ophthalmic)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[54], [48], [55]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[54], [48], [55]
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[43], [66], [67], [48], [68]
D0665
 
Flibanserin
 
C20H21F3N4O
 
6918248 
Moderate    Inter Info   
[69]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[71], [45], [48], [72], [73], [74], [75], [76], [77]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[71], [45], [48], [72], [73], [74], [75], [76], [77]
D1172
 
Olopatadine (nasal)
 
C21H23NO3
 
5281071 
Moderate    Inter Info   
[43], [79], [68]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[71], [45], [48], [72], [73], [74], [75], [76], [77]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[71], [45], [48], [72], [73], [74], [75], [76], [77]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Moderate    Inter Info   
[80]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[71], [73], [75]
   Increased risk of GI mucosal injury/bleeding risk Drug Num:  2
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1318
 
Potassium chloride
 
ClK
 
4873 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]
D1319
 
Potassium citrate
 
C6H5K3O7
 
13344 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [12], [10], [11]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0562
 
Eluxadoline
 
C32H35N5O5
 
11250029 
Moderate    Inter Info   
[48], [65]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of cholinergic agents Drug Num:  12
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0015
 
Acetylcholine
 
C7H16NO2+
 
187 
Moderate    Inter Info   
[17], [18]
D0256
 
Carbamoylcholine (ophthalmic)
 
C6H15N2O2+
 
2551 
Moderate    Inter Info   
[17], [18]
D0440
 
Demecarium (ophthalmic)
 
C32H52N4O4+2
 
5966 
Moderate    Inter Info   
[17], [18]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Moderate    Inter Info   
[59], [60], [61], [62], [63], [64]
D0546
 
Echothiophate (ophthalmic)
 
C9H23NO3PS+
 
10548 
Moderate    Inter Info   
[17], [18]
D0707
 
Galantamine
 
C17H21NO3
 
9651 
Moderate    Inter Info   
[59], [60], [61], [62], [63], [64]
D0856
 
Isoflurophate (ophthalmic)
 
C6H14FO3P
 
5936 
Moderate    Inter Info   
[17], [18]
D1285
 
Physostigmine
 
C15H21N3O2
 
5983 
Moderate    Inter Info   
[59], [60], [61], [62], [63], [64]
D1286
 
Physostigmine (ophthalmic)
 
C15H21N3O2
 
5983 
Moderate    Inter Info   
[17], [18]
D1289
 
Pilocarpine (ophthalmic)
 
C11H16N2O2
 
5910 
Moderate    Inter Info   
[17], [18]
D1418
 
Rivastigmine
 
C14H22N2O2
 
77991 
Moderate    Inter Info   
[59], [60], [61], [62], [63], [64]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[60], [61], [63]
   Diminish the response to diagnostic skin test antigens Drug Num:  3
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1755
 
Candida albicans
 
C29H27N2O12P
 
118855431 
Moderate    Inter Info   
[17], [43], [44]
D1912
 
Trichophyton mentagrophytes
 
NA
 
NA
Moderate    Inter Info   
[17], [43], [44]
D1913
 
Tuberculin purified protein derivative
 
NA
 
NA
Moderate    Inter Info   
[17], [43], [44]
   Attenuated pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[48], [49], [43]
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[67], [43], [70]
D1812
 
Hyaluronidase
 
C17H24BrNO2
 
91820602 
Minor    Inter Info   
[81], [82], [83]
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