Drug General Information (ID: DDINX5YK7R)
Drug Name			Oxytocin		Drug Info		Dinoprostone (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uterotonic Agents				Prostaglandins
Structure

Mechanism of Oxytocin-Dinoprostone (topical) Interaction (Severity Level: Major)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Oxytocin				Dinoprostone (topical)
Mechanism		Potentiate the uterine contraction effect of dinoprostone				Dinoprostone
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Dinoprostone (topical) and Oxytocin

Recommended Action
Management		Infusion of oxytocin should not be started until at least 6 to 12 hours after the use of dinoprostone vaginal gel (6 to 12 hours recommended for Prepidil Gel and 12 to 24 hours for Prostin E2 Vaginal Gel) or at least 30 minutes after the removal of dinoprostone vaginal insert.

References
1	Product Information. Prepidil (dinoprostone topical) Pharmacia and Upjohn, Kalamazoo, MI.
2	Product Information. Cervidil (dinoprostone topical). Forest Pharmaceuticals, St. Louis, MO.
3	Product Information. Prostin E2 (dinoprostone topical). Pharmacia and Upjohn, Kalamazoo, MI.