Drug General Information (ID: DDINEKQXZF)
Drug Name			Acetazolamide		Drug Info		Memantine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticonvulsants				Cholinesterase Inhibitors
Structure

Mechanism of Acetazolamide-Memantine Interaction (Severity Level: Minor)
Altered urine pH Click to Show/Hide Mechanism Graph
Drug Name		Acetazolamide				Memantine
Mechanism		Urine alkalinizer Decrease the renal excretion				Urine pH sensitive
Key Mechanism Factor 1
		Factor Name		Urine pH
		Factor Description		The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
Mechanism Description		Altered elimination of Memantine caused by Acetazolamide mediated altered urine pH

References
1	Product Information. Namenda (memantine). Forest Pharmaceuticals, St. Louis, MO.