Drug General Information (ID: DDIN7JH50B)
Drug Name			Amiodarone		Drug Info		Iodide I-131		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Radiopharmaceuticals
Structure

Mechanism of Amiodarone-Iodide I-131 Interaction (Severity Level: Major)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Amiodarone				Iodide I-131
Mechanism		Interfere with the therapeutic effect and/or diagnostic result of radioiodides				Radioiodide
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Iodide I-131 when combined with Amiodarone

Recommended Action
Management		The use of radioactive iodine therapy for the treatment of amiodarone-induced hyperthyroidism is contraindicated by the manufacturer.

References
1	Libersa CC, Brique SA, Motte KB, et al. "Dramatic inhibition of amiodarone metabolism induced by grapefruit juice." Br J Clin Pharmacol 49 (2000): 373-8. [PMID: 10759694]
2	Product Information. Cordarone Intravenous (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Canadian Pharmacists Association "e-CPS."