Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIMWGJEUK)
  Drug Name Nabumetone Drug Info Donepezil Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Nsaids/Analgesics Cholinesterase Inhibitors
  Structure

 Mechanism of Nabumetone-Donepezil Interaction (Severity Level: Minor)
     Increased risk of GI mucosal injury/bleeding risk Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nabumetone Donepezil
      Mechanism GI mucosal injury/bleeding risk GI mucosal injury/bleeding risk
      Key Mechanism Factor 1
Factor Name Gastrointestinal toxicity
Factor Description The risk and severity of gastrointestinal toxicity, including inflammation, bleeding, ulceration, and perforation, increases when drugs with gastrointestinal mucosal irritant effects are combined.
      Mechanism Description
  • Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Donepezil 

References
1 Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.