Drug General Information (ID: DDIMVHU7D6)
Drug Name			Bacillus calmette-guerin substrain tice live antigen		Drug Info		Human botulinum neurotoxin A/B immune globulin		Drug Info
Drug Type		Vaccine				Polyclonal antibody
Therapeutic Class		Vaccine				Immune Globulins

Mechanism of Bacillus calmette-guerin substrain tice live antigen-Human botulinum neurotoxin A/B immune globulin Interaction (Severity Level: Moderate)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Bacillus calmette-guerin substrain tice live antigen				Human botulinum neurotoxin A/B immune globulin
Mechanism		Vaccine or toxoid				Immunomodulatory effects
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Bacillus calmette-guerin substrain tice live antigen when combined with Human botulinum neurotoxin A/B immune globulin

Recommended Action
Management		Varicella virus vaccine should not be given for at least 5 months, and other live vaccines should not be given for at least 3 months, after administration of immune globulin. If such vaccinations are given shortly before or after immune globulin therapy, a revaccination may be necessary.

References
1	Product Information. Varicella Zoster Immune Globulin (varicella zoster immune globulin). American Red Cross Blood Services, Dedham, MA.
2	Product Information. Vivaglobin (immune globulin subcutaneous). ZLB Bioplasma Inc, Glendale, CA.
3	Product Information. Bayrab (rabies immune globulin, human). Bayer, West Haven, CT.