Details of Drug

Details of Drug

 Drug General Information (ID: D0761)
  Drug Name
Human botulinum neurotoxin A/B immune globulin
  Drug Type Polyclonal antibody
  Drug Synonymous
Botulism immune globulin intravenous (human); Botulism immune globulin intravenous (human) (BIG-IV); Botulism immune globulin IV human; DB14115; Human botulinum neurotoxin A/B immune globulin; Human-derived botulism antitoxin antibodies
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  Therapeutic Class Immune Globulins

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM072  Increased risk of nephrotoxicity
BM100  Antagonize the effect of vaccine/toxoid
  Relation Graph
 Full list of drugs interacting with Human botulinum neurotoxin A/B immune globulin
      Pharmacodynamic additive effects
   Increased risk of nephrotoxicity Drug Num:  65
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0056
 
Amikacin
 
C22H43N5O13
 
37768 
Major    Inter Info   
[1], [2], [3]
D0057
 
Amikacin (liposome)
 
C22H43N5O13
 
37768 
Major    Inter Info   
[1], [2], [3]
D0075
 
Amphotericin B
 
C47H73NO17
 
5280965 
Major    Inter Info   
[1], [2], [3]
D0076
 
Amphotericin B (cholesteryl sulfate)
 
C47H73NO17
 
5280965 
Major    Inter Info   
[1], [2], [3]
D0077
 
Amphotericin B (lipid complex)
 
C47H73NO17
 
5280965 
Major    Inter Info   
[1], [2], [3]
D0078
 
Amphotericin B (liposomal)
 
C47H73NO17
 
5280965 
Major    Inter Info   
[1], [2], [3]
D0142
 
Bacitracin
 
C66H103N17O16S
 
10909430 
Major    Inter Info   
[1], [2], [3]
D0145
 
Balsalazide
 
C17H15N3O6
 
54585 
Major    Inter Info   
[1], [2], [3]
D0210
 
Bromfenac
 
C15H12BrNO3
 
60726 
Major    Inter Info   
[1], [2], [3]
D0252
 
Capreomycin
 
C50H88N28O15
 
3000502 
Major    Inter Info   
[1], [2], [3]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Major    Inter Info   
[1], [2], [3]
D0335
 
Cidofovir
 
C8H14N3O6P
 
60613 
Major    Inter Info   
[1], [2], [3]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Major    Inter Info   
[1], [2], [3]
D0383
 
Colistimethate
 
C58H105N16O28S5-5
 
70789202 
Major    Inter Info   
[1], [2], [3]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Major    Inter Info   
[1], [2], [3]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Major    Inter Info   
[1], [2], [3]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Major    Inter Info   
[1], [2], [3]
D0489
 
Diflunisal
 
C13H8F2O3
 
3059 
Major    Inter Info   
[1], [2], [3]
D0623
 
Etidronic acid
 
C2H8O7P2
 
3305 
Major    Inter Info   
[1], [2], [3]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Major    Inter Info   
[1], [2], [3]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Major    Inter Info   
[1], [2], [3]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Major    Inter Info   
[1], [2], [3]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Major    Inter Info   
[1], [2], [3]
D0709
 
Gallium nitrate
 
GaN3O9
 
61635 
Major    Inter Info   
[1], [2], [3]
D0718
 
Gentamicin
 
C21H43N5O7
 
3467 
Major    Inter Info   
[1], [2], [3]
D0724
 
Givosiran
 
C78H139N11O30
 
119058042 
Major    Inter Info   
[1], [2], [3]
D0805
 
Inotersen
 
C230H318N69O121P19S19
 
121492004 
Major    Inter Info   
[1], [2], [3]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Major    Inter Info   
[1], [2], [3]
D0783
 
Ibandronate
 
C9H23NO7P2
 
60852 
Major    Inter Info   
[1], [2], [3]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Major    Inter Info   
[1], [2], [3]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Major    Inter Info   
[1], [2], [3]
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[1], [2], [3]
D0876
 
Kanamycin
 
C18H36N4O11
 
6032 
Major    Inter Info   
[1], [2], [3]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Major    Inter Info   
[1], [2], [3]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Major    Inter Info   
[1], [2], [3]
D0964
 
Lutetium Lu 177 dotatate
 
C65H87LuN14O19S2
 
76966897 
Major    Inter Info   
[1], [2], [3]
D0991
 
Mefenamic acid
 
C15H15NO2
 
4044 
Major    Inter Info   
[1], [2], [3]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Major    Inter Info   
[1], [2], [3]
D1009
 
Mesalazine
 
C7H7NO3
 
4075 
Major    Inter Info   
[1], [2], [3]
D1091
 
Moxetumomab Pasudotox
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Major    Inter Info   
[1], [2], [3]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Major    Inter Info   
[1], [2], [3]
D1120
 
Neomycin
 
C23H46N6O13
 
8378 
Major    Inter Info   
[1], [2], [3]
D1126
 
Netilmicin
 
C21H41N5O7
 
441306 
Major    Inter Info   
[1], [2], [3]
D1173
 
Olsalazine
 
C14H10N2O6
 
22419 
Major    Inter Info   
[1], [2], [3]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Major    Inter Info   
[1], [2], [3]
D1217
 
Pamidronic acid
 
C3H11NO7P2
 
4674 
Major    Inter Info   
[1], [2], [3]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Major    Inter Info   
[1], [2], [3]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Major    Inter Info   
[1], [2], [3]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Major    Inter Info   
[1], [2], [3]
D1304
 
Plazomicin
 
C25H48N6O10
 
42613186 
Major    Inter Info   
[1], [2], [3]
D1310
 
Polymyxin B
 
C56H98N16O13
 
49800004 
Major    Inter Info   
[1], [2], [3]
D1421
 
Rofecoxib
 
C17H14O4S
 
5090 
Major    Inter Info   
[1], [2], [3]
D1442
 
Salsalate
 
C14H10O5
 
5161 
Major    Inter Info   
[1], [2], [3]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Major    Inter Info   
[1], [2], [3]
D1507
 
Streptomycin
 
C21H39N7O12
 
19649 
Major    Inter Info   
[1], [2], [3]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Major    Inter Info   
[1], [2], [3]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Major    Inter Info   
[1], [2], [3]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Major    Inter Info   
[1], [2], [3]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Major    Inter Info   
[1], [2], [3]
D1597
 
Tobramycin
 
C18H37N5O9
 
36294 
Major    Inter Info   
[1], [2], [3]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Major    Inter Info   
[1], [2], [3]
D1674
 
Valdecoxib
 
C16H14N2O3S
 
119607 
Major    Inter Info   
[1], [2], [3]
D1680
 
Vancomycin
 
C66H75Cl2N9O24
 
14969 
Major    Inter Info   
[1], [2], [3]
D1727
 
Zoledronic acid
 
C5H10N2O7P2
 
68740 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1744
 
Bacillus calmette-guerin substrain tice live antigen
 
NA
 
NA
Moderate    Inter Info   
[4], [5], [6]
References
1 Guo X, Nzerue C "How to prevent, recognize, and treat drug-induced nephrotoxicity.".
2 Centers for Disease Control and Prevention (CDC). Renal insufficiency and failure associated with immune globulin intravenous therapy--United States, 1985-1998.?MMWR Morb Mortal Wkly Rep. 1999;48(24):518-521. [PMID: 10401909]
3 Product Information. BabyBIG (botulism immune globulin). FFF Enterprises, Temecula, CA.
4 Product Information. Varicella Zoster Immune Globulin (varicella zoster immune globulin). American Red Cross Blood Services, Dedham, MA.
5 Product Information. Vivaglobin (immune globulin subcutaneous). ZLB Bioplasma Inc, Glendale, CA.
6 Product Information. Bayrab (rabies immune globulin, human). Bayer, West Haven, CT.