Drug General Information (ID: DDIMUV2B48)
Drug Name			Methylergometrine		Drug Info		Dinoprostone (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Oxytocics				Prostaglandins
Structure

Mechanism of Methylergometrine-Dinoprostone (topical) Interaction (Severity Level: Major)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Methylergometrine				Dinoprostone (topical)
Mechanism		Potentiate the uterine contraction effect of dinoprostone				Dinoprostone
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Dinoprostone (topical) and Methylergometrine

Recommended Action
Management		The concomitant use of dinoprostone with other oxytocic agents is considered contraindicated.

References
1	Product Information. Prostin E2 (dinoprostone topical). Pharmacia and Upjohn, Kalamazoo, MI.
2	Product Information. Prostin E2 Suppository (dinoprostone topical). Pharmacia and Upjohn, Kalamazoo, MI.