Drug General Information (ID: DDIM4KTO6R)
Drug Name			Dimethyl fumarate		Drug Info		Ibrutinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Selective Immunosuppressants				Antineoplastics/Bruton Tyrosine Kinase Inhibitor
Structure

Mechanism of Dimethyl fumarate-Ibrutinib Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Dimethyl fumarate				Ibrutinib
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Dimethyl fumarate and Ibrutinib

Recommended Action
Management		The safety and efficacy of monomethyl fumarate, dimethyl fumarate, or diroximel fumarate in combination with other immunosuppressive or myelosuppressive agents have not been evaluated. Until further information is available, concomitant use should be avoided if possible.

References
1	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.