Details of Drug

Drug General Information (ID: D0785)
Drug Name	Ibrutinib
Drug Type	Small molecule
Drug Synonymous	PCI-32765; Ibrutinib (BTK inhibitor) Click to Show/Hide
Disease Class	2B33: Malignant haematopoietic neoplasm; 2A81: Diffuse large B-cell lymphoma; 2A80: Follicular lymphoma; 2A85: Mature B-cell lymphoma; 2C10: Pancreatic cancer; 2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Antineoplastics/Bruton Tyrosine Kinase Inhibitor
Structure
Structure	3D Structure		2D Structure
Formula	C25H24N6O2
InChI	1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1
InChIKey	XYFPWWZEPKGCCK-GOSISDBHSA-N
Canonical SMILES	C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N
External Link
	Pubchem ID	24821094
	CAS Number	936563-96-1
	CHEBI ID	76612
	TTD ID	D09KTS
	INTEDE ID	DR0843
	VARIDT ID	DR01270

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ibrutinib
Affected cellular transport
	Transporter inhibition					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[12], [32]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[12], [3], [38]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[3], [4]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[3], [4]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[3], [4]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[3], [4]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[3], [4]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[3], [4]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[3], [4]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[3], [4]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[3], [4]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[3], [4]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[3], [117]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[4], [53]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[118]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[3], [119], [4]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[120]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[3], [4]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[130]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[12], [131]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[134]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[135]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[3], [4]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[3], [4]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[3], [4]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[3], [4]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[3], [4]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[3], [4]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[3], [4]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[3], [4]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[3], [4]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[3], [4]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[3], [4]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[3], [4]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[4]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[4]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[4]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[12], [4], [13]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[4]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[12], [4], [13]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[12], [4], [13]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[4]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[4]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[12], [4], [13]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[4]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[4]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[4]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[4]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[4]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[4]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[12], [4], [13]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[12], [4], [13]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[12], [4], [13]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[12], [4], [13]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[4]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[12], [4], [13]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[12], [4], [13]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[12], [4], [13]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[12], [4], [13]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[12], [4], [13]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[12], [4], [13]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[12], [3], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[12], [4], [13]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[12], [4], [13]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[12], [4], [13]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[12], [4], [13]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[4]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[12], [3], [4]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[4], [53]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[4], [53]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[4], [53]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[4], [53]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[3], [4], [98]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[4], [53]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[4], [53]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[4], [53]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[4], [53]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[4], [53]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[4], [53]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[4], [53]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[4], [53]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[4], [53]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[4], [53]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[12], [3], [137], [138]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [53]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[4], [53]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[4], [53]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[4], [53]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[4], [53]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[4], [53]
	CYP450 enzyme induction					Drug Num: 41
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[3], [4]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[3], [4]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[3], [4]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[3], [4]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[3], [4]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[3], [4]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[3], [4]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[3], [4]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[3], [4]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[3], [4]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[3], [4]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[3], [4]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[4]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[4]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[4]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[4]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[4]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[4]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[4]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[4]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[4]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[4]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[4]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[4]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[4]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[4]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [4]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[4]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[3], [4]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[4]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[4]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[4]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[4]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[4]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[4]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[4]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [4]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[4]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[4]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[148], [149], [150], [151], [152]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[148], [149], [150], [151], [152]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[6], [7], [8], [9], [10], [11]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[6], [10], [11]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[3], [15]
D0614		Etanercept	NA	NA	Major		Inter Info	[6], [7], [8], [9], [10], [11]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[24]
D0736		Golimumab	NA	NA	Major		Inter Info	[6], [7], [8], [9], [10], [11]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[12], [3], [30]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[12], [33]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[37]
D0802		Infliximab	NA	NA	Major		Inter Info	[6], [7], [8], [9], [10], [11]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[39], [40]
D1111		Natalizumab	NA	NA	Major		Inter Info	[41]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[39], [40]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[49]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[34], [50], [51]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[52]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[54], [55], [56]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[12], [3]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[54], [55], [56]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[99]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[101]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[102]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[101]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[101]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[121]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[3], [122]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[132]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[12], [3], [133]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[139]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[140]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[143]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[54], [55], [56]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[3], [144]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[145]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[146]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[12], [3], [147]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[3], [16], [17]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[12], [21], [22]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[47]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[12], [3], [106], [107]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[12], [3], [106], [107]
	Increased risk of bleeding					Drug Num: 115
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[5], [2], [3]
D0047		Alteplase	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2], [3], [4]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2], [3], [4]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2], [3], [4]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1], [2], [3], [4]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1], [2], [3], [4]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[14]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1], [2], [3], [4]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2], [3], [4]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2], [3], [4]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[18]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[19], [20]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1], [2], [3], [4]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [2], [3], [4]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[5], [2], [3]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2], [3], [4]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1], [2], [3], [4]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[23]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1], [2], [3], [4]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3], [4]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [2], [3], [4]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [2], [3], [4]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2], [3], [4]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[5], [2], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[25]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[5], [2], [3]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[3], [26]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1], [2], [3], [4]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1], [2], [3], [4]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1], [2], [3], [4]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [2], [3], [4]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2], [3], [4]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[4]
D0663		Flax seed	NA	NA	Major		Inter Info	[5], [2], [3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[3], [19], [31]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Major		Inter Info	[5], [2], [3]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1], [2], [3], [4]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[19]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [2], [3], [4]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1], [2], [3], [4]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [2], [3], [4]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [2], [3], [4]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2], [3], [4]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2], [3], [4]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[5], [2], [3]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [2], [3], [4]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [2], [3], [4]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [2], [3], [4]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [2], [3], [4]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [2], [3], [4]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[12], [3], [42]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1], [2], [3], [4]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1], [2], [3], [4]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1], [2], [3], [4]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[43]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1], [2], [3], [4]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[44]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[3], [45], [46]
D1395		Reteplase	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1], [2], [3], [4]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1], [2], [3], [4]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1], [2], [3], [4]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1], [2], [3], [4]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [2], [3], [4]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1], [2], [3], [4]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1], [2], [3], [4]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[48]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3], [4]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [2], [3], [4]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[5], [2], [3]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[5], [2], [3]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1], [2], [3], [4]
D1669		Urokinase	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D1703		Vitamin E	C29H50O2	14985	Major		Inter Info	[1], [2], [3], [4]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[1], [2], [3], [4]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2], [3], [4]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[57], [58], [59]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[19], [100]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[57], [58], [59]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[57], [58], [59]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[57], [58], [59]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[108]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[57], [58], [59]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[57], [58], [59]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[19], [142]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[57], [58], [59]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[60], [61], [62], [63], [12], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[27], [28], [29]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[27], [28], [29]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[27], [28], [29]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[27], [28], [29]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[27], [28], [29]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[34], [12], [35]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[36]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[27], [28], [29]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[27], [28], [29]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[27], [28], [29]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[34], [109], [110]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[34], [109], [110]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[34], [109], [110]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[34], [109], [110]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[34], [109], [110]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[34], [109], [110]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[34], [109], [110]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[34], [109], [110]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[123], [34], [12], [124], [125], [126], [109], [127], [128], [129], [110]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[34], [109], [110]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[34], [109], [110]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[136]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[111], [112], [113]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[111], [112], [113]
	Diminish the response to diagnostic skin test antigens					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[114], [115], [116]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[114], [115], [116]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[103], [104], [105]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[19], [141]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[103], [104], [105]

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35	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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38	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
39	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
40	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
41	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
42	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
43	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
44	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
45	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
46	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
47	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
48	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
49	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
50	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
51	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
52	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
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88	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
89	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
90	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
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102	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
103	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
104	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
105	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
106	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
107	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
108	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.
109	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
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115	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
116	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
117	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
118	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
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122	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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124	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
125	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
126	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
127	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
128	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
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130	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
131	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
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141	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
142	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
143	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
144	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
145	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
146	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
147	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
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149	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
150	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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