Drug General Information (ID: DDIM2KH0UE)
Drug Name			Lanthanum carbonate		Drug Info		Thyroid, porcine		Drug Info
Drug Type		Small molecule				Hormones
Therapeutic Class		Phosphate Binders				Thyroid Drugs

Mechanism of Lanthanum carbonate-Thyroid, porcine Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Lanthanum carbonate				Thyroid, porcine
Mechanism		Anion exchange resin/polymer				Binds to anion exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Lanthanum carbonate due to formation of complexes caused by Thyroid, porcine

Recommended Action
Management		Levothyroxine should be administered at least 4 hours apart from phosphate binders. It is recommended that TSH levels be monitored more closely during concomitant use.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Renagel (sevelamer). Genzyme Corporation, Cambridge, MA.
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]