Drug General Information (ID: DDILP0BA35)
Drug Name			Ibandronate		Drug Info		Magnesium oxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bone Density Conservation Agents				Minerals And Electrolytes
Structure

Mechanism of Ibandronate-Magnesium oxide Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Ibandronate				Magnesium oxide
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Magnesium oxide due to formation of complexes caused by Ibandronate

Recommended Action
Management		Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose.

References
1	Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]
2	Product Information. Actonel (risedronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
3	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
4	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
5	Product Information. Fosamax (alendronate). Merck & Co, Inc, West Point, PA.
6	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.