Drug General Information (ID: DDIL9NVO2R)
Drug Name			Quinidine		Drug Info		Troleandomycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Group I Antiarrhythmics				Antibiotics
Structure

Mechanism of Quinidine-Troleandomycin Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Quinidine				Troleandomycin
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Quinidine and Troleandomycin

Recommended Action
Management		The use of quinidine in combination with macrolide antibiotics should be avoided. Patients treated with these agents should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitations, irregular heartbeat, shortness of breath, or syncope.

References
1	Damkier P, Hansen LL, Brosen K "Effect of fluvoxamine on the pharmacokinetics of quinidine." Eur J Clin Pharmacol 55 (1999): 451-6. [PMID: 10492058]
2	Lin JC, Quasny HA "QT prolongation and development of torsades de pointes with the concomitant administration of oral erythromycin base and quinidine." Pharmacotherapy 17 (1997): 626-30. [PMID: 9165570]
3	Product Information. ERYC (erythromycin). Parke-Davis, Morris Plains, NJ.
4	Spinler SA, Cheng JWM, Kindwall KE, Charland SL "Possible inhibition of hepatic metabolism of quinidine by erythromycin." Clin Pharmacol Ther 57 (1995): 89-94. [PMID: 7828386]