Details of Drug

Drug General Information (ID: D1653)
Drug Name	Troleandomycin
Drug Type	Small molecule
Drug Synonymous	Aovine; Cyclamycin; Evramicina; Matromicina; Oleandocetin; Oleandocetine; TAO; Treolmicina; Triacetyloleandomycin; Triacetyloleandomycinum; Tribiocillina; Triocetin; Triolan; Troleandomicina; Troleandomycine; Troleandomycinum; Viamicina; Wytrion; Matromycin T; Oleandomycin triacetate; Oleandomycin triacetyl ester; Triacetyl ester of oleandomycin; WY 651; Tao (TN); Tao (VAN); Tekmisin (TN); Treis-Micina; Triacetyloleandomycin (JAN); Triocetin (TN); Troleandomicina [INN-Spanish]; Troleandomycin (TAO); Troleandomycin [USAN:INN]; Troleandomycine [INN-French]; Troleandomycinum [INN-Latin]; Oleandomycin, triacetate (ester); T.A.O; Troleandomycin (USP/INN); T.A.O. Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C41H67NO15
InChI	1S/C41H67NO15/c1-19-17-41(18-49-41)38(46)23(5)34(53-27(9)43)21(3)25(7)52-39(47)24(6)35(56-32-16-31(48-14)36(26(8)51-32)54-28(10)44)22(4)33(19)57-40-37(55-29(11)45)30(42(12)13)15-20(2)50-40/h19-26,30-37,40H,15-18H2,1-14H3/t19-,20+,21-,22+,23+,24+,25+,26-,30-,31-,32-,33-,34-,35-,36-,37+,40-,41+/m0/s1
InChIKey	LQCLVBQBTUVCEQ-QTFUVMRISA-N
Canonical SMILES	CC1CC(C(C(O1)OC2C(CC3(CO3)C(=O)C(C(C(C(OC(=O)C(C(C2C)OC4CC(C(C(O4)C)OC(=O)C)OC)C)C)C)OC(=O)C)C)C)OC(=O)C)N(C)C
External Link
	Pubchem ID	202225
	CAS Number	311074
	CHEBI ID	45735
	TTD ID	D06IGU
	INTEDE ID	DR1652
	VARIDT ID	DR00543

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Troleandomycin
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[632], [633]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[632], [633]
Affected cellular transport
	Transporter inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[17], [18], [500]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[526], [201], [527], [528], [529], [530], [531], [532], [533], [534], [535], [536], [409], [537], [538], [539], [540], [541], [414], [542], [543], [544], [545], [546], [547], [548], [549], [550], [551], [552], [553], [554], [555], [556], [557], [558], [559], [560], [561], [562], [563]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[624]
D0656		Fexofenadine	C32H39NO4	3348	Minor		Inter Info	[746], [747]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[17], [18], [748]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 256
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[1]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[2]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[17], [18], [19], [20], [21]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[22], [23], [24], [25], [26], [27], [28]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[17], [20], [52]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[17], [18], [53], [20]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[54]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[55], [17], [18], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[69]
D0228		Cabergoline	C26H37N5O2	54746	Major		Inter Info	[70], [71], [18], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[85]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[17], [20], [86]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[18], [87], [88], [89]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[17], [90], [20]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[17], [91], [20], [92]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[93]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[17], [20], [94]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[18], [95]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[70], [71], [18], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[17], [18], [96], [97], [98], [99], [100], [101], [102], [103], [25], [104], [105]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[106], [17], [18], [107], [108], [20], [109], [110], [111], [112]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[17], [18], [113], [114], [115], [66], [116]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[117], [118], [119]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[120], [118], [119]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[121]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[17], [18], [122], [20]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[123]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[18], [124], [125], [126]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[18], [127]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[17], [128], [20]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[129]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[130], [131], [72], [132], [133]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[17], [134], [135], [20]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[18], [136]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[17], [137], [138], [139], [20], [140], [15]
D0655		Fesoterodine	C26H37NO3	6918558	Major		Inter Info	[17], [20], [141], [142]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[143]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[144]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[145]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[146]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[18], [147]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[18], [148]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[149], [150]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[151]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[152], [17], [18], [153], [154], [155], [156]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[18], [153], [154]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[157]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[158], [118], [119]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[17], [18], [159], [20]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[17], [18], [160], [161], [162], [163]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[17], [20], [164]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[17], [167]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[17], [168], [20]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[169]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[170], [171], [172], [173], [174], [175]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[176]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[177]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[178]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[78], [81], [84]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[179], [19], [180], [181], [182], [183], [184], [185]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[78], [81], [84]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[186], [187]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[188], [189]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[17], [18], [191], [20]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[192], [17], [193]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[17], [18], [194], [20]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[195], [118], [119]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[196]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[17], [18], [197]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[198]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[199], [119]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[200]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[201], [202], [203], [204], [205], [206], [207], [208]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[209]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[17], [18], [210]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[224], [225], [226], [227], [228], [229], [230], [231], [232]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[18], [233]
D1440		Salmeterol	C25H37NO4	5152	Major		Inter Info	[17], [18], [234], [20]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[235]
D1465		Sildenafil	C22H30N6O4S	135398744	Major		Inter Info	[17], [18], [236], [237], [238], [239], [240], [241], [20], [242], [243]
D1466		Silodosin	C25H32F3N3O4	5312125	Major		Inter Info	[17], [244], [20]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[17], [245], [20]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[30], [246], [31], [33], [247], [72], [34], [248], [35], [249], [250], [36], [251], [252], [37], [253], [254], [255], [256], [257], [258], [259], [260], [39], [261], [40], [262], [263], [41], [264], [265], [44], [45], [266], [47], [267], [48], [268], [269], [270], [50], [51]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[17], [271]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[17], [272], [273], [274], [275], [276], [20], [118], [66]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[17], [18], [20], [141], [277]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[278]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[17], [279]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[280], [18], [281], [282], [134], [283], [284], [285], [286], [287], [288], [289], [103], [206], [290], [291], [292]
D1534		Tamsulosin	C20H28N2O5S	129211	Major		Inter Info	[17], [293], [294], [295], [20]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[296]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[17], [18], [298], [20]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[17], [18], [299]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[17], [91], [20], [92]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[300]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[17], [18], [301]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[179], [302], [303], [19], [304], [305], [306], [307], [308], [309], [310], [311]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[18], [312]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[149], [150], [313]
D0683		Fluticasone	C22H27F3O4S	5311101	Major		Inter Info	[314], [315], [316], [317], [56], [318], [319], [320], [321], [322], [323], [324], [325], [61], [326], [327], [328], [63], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Major		Inter Info	[337], [338], [350]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[351], [119]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[17], [18], [352]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[353], [354]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[355]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[356], [119]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[17], [357]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[358], [119]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[361]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[362]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[363], [353], [364]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[366]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[367]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[368], [369], [370], [371], [372], [373], [152], [374], [17], [18], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [20], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[368], [369], [370], [371], [372], [373], [152], [374], [17], [18], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [20], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[371], [393], [395]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[368], [369], [370], [371], [372], [373], [152], [374], [17], [18], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [20], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[17], [20], [405]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[406], [407], [408], [18], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[423]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[152], [18], [424], [425]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[426]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[427]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[201], [17], [18], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[441], [201], [442], [443], [444], [445], [446], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469], [470], [471]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[18], [472], [473]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[474]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[486]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[487]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[179], [315], [55], [488], [489], [59], [19], [490], [491], [180], [322], [323], [492], [181], [182], [183], [493], [62], [494], [67], [68], [342], [495], [184], [185], [496], [497], [498], [349]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[17], [18], [499]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[501], [502], [503]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[504]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[118], [505], [119]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[55], [17], [18]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[506]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[17], [507], [20]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[508]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[17]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[179], [19], [509], [510]
D0334		Ciclesonide (nasal)	C32H44O7	6918155	Moderate		Inter Info	[511], [512], [509]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[17], [18], [513], [514], [515]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[516]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[517]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[519], [520]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[17], [18], [103], [521]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[17], [20], [522]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[523]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[524], [525]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Moderate		Inter Info	[59], [490], [342]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[564], [565], [566], [567], [184]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[568]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[152], [18], [569]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[179], [477], [17], [18], [570], [571], [572]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[573]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[574]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[575]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[576], [577]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[582]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[583], [584]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[585], [586], [587], [588], [589], [72], [590], [591], [592], [593], [594], [595], [596], [597], [598], [599], [600], [601]
D0672		Flunisolide	C24H31FO6	82153	Moderate		Inter Info	[59], [490], [342]
D0673		Flunisolide (nasal)	C24H31FO6	82153	Moderate		Inter Info	[59], [490], [342]
D0674		Fluorometholone (ophthalmic)	C22H29FO4	9878	Moderate		Inter Info	[59], [490], [342]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[602], [603], [604], [605], [606]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[220], [607]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[608], [609]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[611]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[179], [315], [55], [488], [489], [59], [19], [490], [491], [180], [322], [323], [492], [181], [182], [183], [493], [62], [494], [67], [68], [342], [495], [184], [185], [496], [497], [498], [349]
D0774		Hydrocortisone (ophthalmic)	C21H30O5	5754	Moderate		Inter Info	[59], [490], [342]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[17]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[613]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[619], [20]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[18], [620]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[17], [18], [621]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[152], [17], [18], [622], [623]
D0955		Loteprednol (ophthalmic)	C21H27ClO5	9865442	Moderate		Inter Info	[59], [490], [342]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[625], [626], [627], [628], [629], [630], [521], [631]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[18], [634]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[602], [603], [604], [605], [606]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[636]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[639]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[152], [17], [18]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[640]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[641], [642], [17], [643], [644], [645], [646], [110]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[641], [642], [17]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[18], [647]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[602], [603], [604], [605], [606]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[17], [18], [651]
D1333		Prednisolone (ophthalmic)	C21H28O5	5755	Moderate		Inter Info	[59], [490], [342]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[179], [315], [55], [488], [489], [59], [19], [490], [491], [180], [322], [323], [492], [181], [182], [183], [493], [62], [494], [67], [68], [342], [495], [184], [185], [496], [497], [498], [349]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[652], [653]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[654]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[17], [20], [655]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[656], [657], [658], [659], [660], [661], [662]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[663], [664], [665], [666], [469], [667], [668], [669]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[672], [337], [276]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[17], [18], [673]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[674], [118], [119]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[624]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[675], [676]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[18], [677]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[18], [19], [679]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[680], [681], [140]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[17], [20], [682]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[17], [683], [684], [20]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[441], [201], [442], [443], [444], [445], [446], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469], [470], [471]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[687], [688]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[17], [689], [20]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[690], [691], [692], [693], [694], [695], [696], [697], [698], [337], [699], [700], [486], [521], [636]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[701], [702], [703], [704], [705], [706], [707], [708], [709], [710], [711]
D1629		Triamcinolone (nasal)	C21H27FO6	31307	Moderate		Inter Info	[59], [490], [342]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[59], [490], [342]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[201], [428], [429], [430], [431], [432], [433], [435], [436], [437], [438], [439], [440]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[716], [473]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[717]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[17], [18], [718]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[17], [18], [118]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[719], [720], [721], [722], [723], [337], [724]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[725], [726]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[727]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[728], [695], [729]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[17], [730], [731]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[18], [732]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[733], [734]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[735]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[736], [737], [738]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[739]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[740], [741], [742], [743]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[744]
D0589		Eravacycline	C27H31FN4O8	54726192	Minor		Inter Info	[745]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[733], [734]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[728], [695], [729]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[749]
D0950		Loratadine	C22H23ClN2O2	3957	Minor		Inter Info	[750], [751], [752]
D0954		Losartan	C22H23ClN6O	3961	Minor		Inter Info	[753]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[17], [730], [731]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[754]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[755]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[756]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[757], [758], [759], [760], [761], [762], [763]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[764], [765], [766]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[754]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[18], [767]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[768], [769], [770], [771]
	CYP450 enzyme induction					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[17], [20], [297]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[17], [18], [581]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[610], [152], [17], [18], [581]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[17], [18], [581]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[17], [18], [637], [638]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[610], [152], [17], [18], [581]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[670], [671]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[17], [18], [678]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[17], [712]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[17], [18], [678]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[365]
	Increased risk of hepatotoxicity					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[152], [165], [166]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[190]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[152], [165], [166]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[475], [476], [477], [17], [18], [478], [479], [480], [481], [482], [483], [484], [485]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[476], [17], [484]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[518]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[612]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[615], [616], [617], [618]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[615], [616], [617], [618]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[635]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[615], [616], [617], [618]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[685], [686]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[475], [476], [477], [17], [18], [478], [479], [480], [481], [482], [483], [484], [485]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[17], [18], [713], [714], [715]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[220], [221], [222], [223]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[18], [359], [360]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[578], [579], [580]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[578], [579], [580]
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[614]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[578], [579], [580]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[648], [649], [650]

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82	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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93	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
94	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
95	Product Information. Emflaza (deflazacort). Marathon Pharmaceuticals, Deerfield, IL.
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116	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
117	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
118	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
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121	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
122	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
123	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
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126	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
127	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
128	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
129	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
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133	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
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136	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
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139	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
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142	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
143	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
144	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
145	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
146	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
147	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
148	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
149	Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA "CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes." Br J Clin Pharmacol 57 (2004): 287-97. [PMID: 14998425]
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151	Product Information. Fanapt (iloperidone). Vanda Pharmaceuticals Inc, Rockville, MD.
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156	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
157	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
158	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
159	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
160	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
161	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
162	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
163	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
164	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
165	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
166	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
167	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
168	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
169	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
170	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
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173	Product Information. Imodium (loperamide). Janssen Pharmaceutica, Titusville, NJ.
174	Tayrouz Y, Ganssmann B, Ding R, et al. "Ritonavir increases loperamide plasma concentrations without evidence for P-glycoprotein involvement." Clin Pharmacol Ther 70 (2001): 405-14. [PMID: 11719726]
175	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
176	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
177	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
178	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
179	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
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187	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
188	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
189	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
190	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
191	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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193	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
194	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
195	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
196	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
197	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
198	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
199	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
200	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
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300	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
301	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
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335	Product Information. Flonase (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
336	Product Information. Flovent (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
337	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
338	Product Information. Veramyst (fluticasone nasal). GlaxoSmithKline, Research Triangle Park, NC.
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352	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
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473	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
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482	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
483	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
484	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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499	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
500	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
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505	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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507	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
508	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
509	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
510	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
511	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
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515	Product Information. Zantac (ranitidine). Glaxo Wellcome, Research Triangle Park, NC.
516	Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
517	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
518	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
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523	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
524	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
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568	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
569	Product Information. Cardura (doxazosin). Pfizer US Pharmaceuticals, New York, NY.
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571	Product Information. Droperidol (droperidol). Abbott Pharmaceutical, Abbott Park, IL.
572	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
573	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
574	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
575	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
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596	Product Information. Diflucan (fluconazole). Roerig Division, New York, NY.
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607	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
608	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
609	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
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611	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
612	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
613	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
614	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
615	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
616	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
617	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
618	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
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621	Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
622	Product Information. Norvasc (amlodipine). Pfizer US Pharmaceuticals, New York, NY.
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624	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
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632	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
633	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
634	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
635	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
636	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
637	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
638	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
639	Geronimo-Pardo M, Cuartero-Del-Pozo AB, Jimenez-Vizuete JM, Cortinas-Saez M, Peyro-Garcia R "Clarithromycin-nifedipine interaction as possible cause of vasodilatory shock." Ann Pharmacother 39 (2005): 538-42. [PMID: 15703161]
640	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
641	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
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644	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
645	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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647	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
648	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
649	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
650	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
651	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
652	Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
653	Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK "Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites." Mol Pharmacol 43 (1993): 120-6. [PMID: 8423765]
654	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
655	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
656	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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660	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
661	Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
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670	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
671	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
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676	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
677	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
678	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
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686	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
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698	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
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718	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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731	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
732	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
733	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
734	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
735	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
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739	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
740	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
741	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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745	Product Information. Xerava (eravacycline). Tetraphase Pharmaceuticals, Inc, Watertown, MA.
746	Product Information. Allegra (fexofenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.
747	Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.
748	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
749	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
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755	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
756	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
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762	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
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766	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
767	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
768	Miceli JJ, Smith M, Robarge L, Morse T, Laurent A "The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s71-6. [PMID: 10771458]
769	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
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