Drug General Information (ID: DDIL2PNOVS)
  Drug Name Trazodone Drug Info Ginkgo biloba Drug Info
  Drug Type Small molecule Natural product
  Therapeutic Class Antidepressants Herbal Products

 Mechanism of Trazodone-Ginkgo biloba Interaction (Severity Level: Moderate)
     Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Trazodone Ginkgo biloba
      Mechanism Extrapyramidal effects Extrapyramidal effects
      Key Mechanism Factor 1
Factor Name Adverse reactions
Factor Description An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
      Mechanism Description
  • Increased risk of adverse reactions by the combination of Trazodone and Ginkgo biloba 

Recommended Action
      Management In general, patients should consult a healthcare provider before taking any herbal or alternative medicine. Caution may be appropriate when combining ginkgo products with trazodone, especially in the elderly. Patients should be advised of the potential for increased sedation or other central nervous system effects.

References
1 Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
2 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3 Galluzzi S, Zanetti O, Binetti G, Trabucchi M, Frisoni GB "Coma in a patient with Alzheimer's disease taking low dose trazodone and ginkgo biloba." J Neurol Neurosurg Psychiatry 68 (2000): 679-83