Details of Drug-Drug Interaction
| Drug General Information (ID: DDIKS56DN8) | |||||||||
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| Drug Name | Cefaclor | Drug Info | Aluminum hydroxide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antibiotics | Antacids | |||||||
| Structure | |||||||||
| Mechanism of Cefaclor-Aluminum hydroxide Interaction (Severity Level: Moderate) | |||||||||
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| Complex formation Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Cefaclor | Aluminum hydroxide | |||||||
| Mechanism | Binds to polyvalent cations | Polyvalent cations | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Chelation | ||||||||
| Factor Description | Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | It is recommended that medications that contain aluminum or magnesium hydroxide not be administered within one hour of cefaclor extended release. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Ceclor (cefaclor). Lilly, Eli and Company, Indianapolis, IN. | ||||||||||||||||||